GAP43
GAP43 (growth associated protein 43, also known as neuromodulin, B-50 and PP46) is a neuronal protein associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Browse Assay Genie's current range of GAP43 research reagents below, or read on for the biology behind the target.
GAP43 is associated with nerve growth and is a major component of the motile growth cones at the tips of elongating axons. It plays a role in the induction of axonal and dendritic filopodia. Because it is expressed at high levels in neuronal growth cones during development and axonal regeneration, it has been termed a 'growth' or 'plasticity' protein, and it is considered a crucial component of an effective regenerative response in the nervous system.
The GAP43 gene encodes a member of the neuromodulin family. UniProt lists the protein at the cell membrane, including the growth cone membrane and the filopodium membrane, and at the synapse. It is also annotated in the perikaryon, dendrites, axons and cytoplasm. This spread across neuronal compartments fits its role in growth and remodelling of neuronal processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported for the gene.
The protein is known by several names. UniProt uses neuromodulin, while B-50, PP46 and GAP-43 appear as aliases alongside the HGNC name, growth associated protein 43. Mouse and rat both carry a Gap43 ortholog, so the protein can be studied in common rodent models of neural development and regeneration. Researchers working on axon outgrowth, growth cone biology and nervous system repair commonly use GAP43 as a marker of these processes.
GAP43 is a major component of the motile growth cones at the tips of elongating axons, linking it to nerve growth.
GAP43 is highly expressed during axonal regeneration and is considered a crucial component of an effective regenerative response in the nervous system.
GAP43 is expressed at high levels in neuronal growth cones during development, making it a useful reference for developing neural circuits.
GAP43 plays a role in inducing axonal and dendritic filopodia and is found at the synapse and in dendrites.
GAP43 is associated with nerve growth and is a major component of the motile growth cones at the tips of elongating axons. It plays a role in inducing axonal and dendritic filopodia, and is considered crucial for an effective regenerative response in the nervous system.
GAP43 is also called neuromodulin, B-50, PP46 and GAP-43, and its HGNC name is growth associated protein 43. NCBI Gene reports alternatively spliced transcript variants that encode distinct isoforms. Check the datasheet of any product for its validated reactivity.
NCBI Gene notes that GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. Mouse and rat each have a Gap43 ortholog, which supports comparative studies.
Other targets with products at Assay Genie, including common housekeeping controls used alongside neuronal markers.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P17677; product specifications from Assay Genie datasheets.