NID2
NID2 (nidogen 2, also written Nidogen-2) is a cell-adhesion glycoprotein found in basement membranes. It binds collagens I and IV, perlecan and laminin 1, and is thought to contribute to cell–extracellular matrix interactions. Browse Assay Genie's current range of NID2 research reagents below, or read on for the biology behind the target.
NID2 is a cell-adhesion glycoprotein that is widely distributed in basement membranes. It binds to collagens I and IV, to perlecan and to laminin 1. It does not bind fibulins. These interactions suggest that the NID2 protein probably has a role in cell–extracellular matrix interactions, and it may help maintain the structure of the basement membrane.
The NID2 gene encodes a member of the nidogen family of basement membrane proteins. The mature protein is secreted into the extracellular space, where it becomes part of the extracellular matrix and, more specifically, the basement membrane. The mouse and rat orthologs are both named Nid2, which allows comparative work in common rodent models.
NID2 is closely related to Nidogen-1, the other nidogen family member, and the two are often studied together when researchers examine how basement membrane components are organised. The source annotations describe NID2 mainly in terms of its binding properties, so its study is typically framed around matrix assembly and adhesion. Researchers investigating basement membrane composition may use an NID2 antibody or NID2 ELISA kit to measure or localise the protein in their experimental systems.
NID2 is widely distributed in basement membranes and may help maintain their structure, making it a relevant component to study.
As a cell-adhesion glycoprotein, NID2 probably has a role in cell–extracellular matrix interactions.
NID2 binds collagens I and IV, perlecan and laminin 1, offering a way to explore matrix protein associations.
NID2 belongs to the nidogen family, so it is useful for comparing related basement membrane proteins such as Nidogen-1.
NID2 is a cell-adhesion glycoprotein widely distributed in basement membranes. It binds collagens I and IV, perlecan and laminin 1, but not fibulins. It probably has a role in cell–extracellular matrix interactions and may help maintain basement membrane structure.
The HGNC gene name is nidogen 2, and UniProt lists the protein as Nidogen-2. No alternative symbols or previous names are recorded in the supplied data, so NID2, nidogen 2 and Nidogen-2 cover the common usage.
Yes. Both the mouse and the rat have an ortholog named Nid2, so rodent models can be used to study the gene. Check the datasheet of any product for its validated reactivity.
Another nidogen family basement membrane protein with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14112; product specifications from Assay Genie datasheets.