WBP2
WBP2 (WW domain binding protein 2, also known as WBP-2 or GRAMD6) is a transcriptional coactivator of the oestrogen and progesterone receptors. It acts in the cytoplasm and nucleus, and it belongs to the GRAM domain containing gene group. Browse Assay Genie's current range of WBP2 research reagents below, or read on for the biology behind the target.
WBP2 functions as a transcriptional coactivator of oestrogen receptor alpha (ESR1) and the progesterone receptor (PGR) once these receptors are activated by hormone. In the presence of oestrogen, WBP2 binds to ESR1-responsive promoters. It also synergises with YAP1 to enhance PGR activity. Through its regulation of ESR1, ESR2 and PGR, WBP2 modulates the expression of post-synaptic scaffolding proteins.
The name refers to the WW domain, a globular module of 38 to 40 semiconserved amino acids found in proteins with structural, regulatory and signalling roles. WW domains mediate protein-protein interactions by binding polyproline ligands. The WBP2 gene encodes a WW domain binding protein, which is the basis of its name, and the protein is found in both the cytoplasm and the nucleus. HGNC places it in the GRAM domain containing group, and GRAMD6 is a recorded alias alongside WBP-2.
Defects in the WBP2 gene have been associated with hearing impairment, according to the NCBI Gene summary. Together with its role in steroid receptor signalling and its link to post-synaptic scaffolding proteins, this makes WBP2 a useful subject for studies of hormone-responsive transcription. Orthologues are annotated in mouse and rat, both named Wbp2, so the protein can be studied in common rodent models. Researchers working on WBP2 often use a WBP2 antibody or a WBP2 ELISA kit to follow expression, and recombinant WBP2 protein to examine interactions.
WBP2 coactivates oestrogen receptor alpha and binds ESR1-responsive promoters in the presence of oestrogen, making it relevant to hormone-driven transcription.
WBP2 synergises with YAP1 to enhance progesterone receptor activity, providing a route into PGR coactivation mechanisms.
WBP2 modulates expression of post-synaptic scaffolding proteins through regulation of ESR1, ESR2 and PGR.
Defects in the WBP2 gene have been associated with hearing impairment, supporting its study in genetic and functional hearing research.
WBP2 is a transcriptional coactivator of oestrogen receptor alpha (ESR1) and the progesterone receptor (PGR) after hormone activation. With oestrogen present it binds ESR1-responsive promoters, and it synergises with YAP1 to enhance PGR activity. It also modulates post-synaptic scaffolding protein expression.
The approved HGNC name is WW domain binding protein 2. Recorded aliases are WBP-2 and GRAMD6, the latter reflecting its place in the GRAM domain containing gene group. UniProt calls the protein WW domain-binding protein 2. No previous HGNC names are listed.
Mouse and rat both carry a Wbp2 orthologue. NCBI Gene reports that defects in the human gene have been associated with hearing impairment. Check the datasheet of any product for its validated reactivity before using it in a particular species.
A related WW domain binding protein family member with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q969T9; product specifications from Assay Genie datasheets.