HSPB2
HSPB2 (heat shock protein family B (small) member 2, also known as MKBP) is a small heat shock protein of the HSP20 family that is expressed preferentially in heart and skeletal muscle. It is reported to regulate the kinase DMPK. Browse Assay Genie's current range of HSPB2 research reagents below, or read on for the biology behind the target.
HSPB2 is a member of the small heat shock protein superfamily. Its annotated function is to regulate the kinase DMPK, the myotonic dystrophy protein kinase. According to the NCBI Gene summary, DMPK plays an important role in maintaining muscle structure and function, which places HSPB2 in the biology of striated muscle.
The HSPB2 gene encodes a protein that belongs to the small heat shock protein (HSP20) family. Like other family members, it contains a conserved alpha-crystallin domain at the C-terminal part of the molecule. Expression is described as preferential in the heart and skeletal muscle. UniProt records the protein in the cytoplasm and the nucleus. Mouse and rat orthologs are both designated Hspb2, which allows comparative work in common model organisms.
HGNC places the gene in the small heat shock proteins group, with the approved name heat shock protein family B (small) member 2. Earlier names include heat shock 27kD protein 2 and heat shock 27kDa protein 2, and the protein is also known as MKBP. Researchers studying the HSPB2 gene or protein often consider it alongside other small heat shock proteins that share the alpha-crystallin domain, particularly in a muscle context.
HSPB2 is expressed preferentially in heart and skeletal muscle, making it a relevant protein for studying muscle-specific stress-protein biology.
HSPB2 may regulate the kinase DMPK, which contributes to maintaining muscle structure and function.
As an HSP20 family member with an alpha-crystallin domain, HSPB2 is useful for comparing roles across the small heat shock protein group.
Preferential expression in the heart supports the use of HSPB2 as a target when investigating cardiac tissue protein regulation.
HSPB2 is a small heat shock protein that may regulate the kinase DMPK, according to UniProt. The NCBI Gene summary adds that DMPK, the myotonic dystrophy protein kinase, is important for maintaining muscle structure and function. The protein is found in the cytoplasm and nucleus.
HSPB2 is the approved HGNC symbol for heat shock protein family B (small) member 2. Aliases and previous symbols include MKBP and Hs.78846, and previous names include heat shock 27kD protein 2 and heat shock 27kDa protein 2. UniProt lists it as heat shock protein beta-2.
Orthologs of the human HSPB2 gene are designated Hspb2 in both mouse and rat. The protein belongs to the conserved small heat shock protein (HSP20) family, defined by a C-terminal alpha-crystallin domain. Check the datasheet of any product for its validated reactivity.
Other small heat shock proteins and related heat shock protein targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16082; product specifications from Assay Genie datasheets.