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GNG5
GNG5 (G protein subunit gamma 5) is the gamma chain of a heterotrimeric G protein, a membrane-associated transducer that relays signals from cell surface receptors to internal effectors. It is also known as guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5. Browse Assay Genie's current range of GNG5 research reagents below, or read on for the biology behind the target.
GNG5 is a gamma subunit of the guanine nucleotide-binding proteins (G proteins), which act as modulators or transducers in many transmembrane signalling systems. G proteins are trimeric, made up of alpha, beta and gamma chains, and they regulate the flow of information from cell surface receptors to a variety of internal metabolic effectors.
When a G protein interacts with its activated receptor, GTP is exchanged for the GDP bound to the alpha subunit. The alpha-GTP complex then dissociates from the beta-gamma heterodimer, and each part can in turn interact with and regulate effector molecules. The beta and gamma chains are required for GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. GNG5 therefore contributes to signal transduction as part of the beta-gamma dimer. The protein is found at the cell membrane.
The GNG5 gene encodes a member of the G protein gamma family and is classed by HGNC in the G protein subunits gamma group. Its previous name was guanine nucleotide binding protein (G protein), gamma 5. Mouse and rat orthologs, both named Gng5, are recognised, which allows the protein to be studied in common rodent models. Researchers interested in G protein signalling use GNG5 as a defined gamma subunit when examining receptor-to-effector transduction.
GNG5 is a gamma chain of the trimeric G proteins that carry information from activated receptors to internal effectors.
The beta and gamma chains are required for G protein-effector interaction, making GNG5 relevant to studies of how signals reach downstream targets.
Gamma chains, with beta chains, are needed for GTPase activity and for replacement of GDP by GTP on the G protein.
As a cell membrane protein acting in transmembrane signalling, GNG5 is a subject for work on how membrane-associated G proteins regulate cell responses.
GNG5 is a gamma subunit of heterotrimeric G proteins, which modulate or transduce signals across the membrane. With the beta chain it forms a dimer needed for GTPase activity, GDP-to-GTP exchange and G protein-effector interaction, and it can regulate effectors after separating from the alpha subunit.
The HGNC name is G protein subunit gamma 5, and the previous name was guanine nucleotide binding protein (G protein), gamma 5. UniProt lists it as guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5. No other aliases or previous symbols are recorded.
Yes. Both mouse and rat have an ortholog named Gng5, so the target can be studied in these rodent models. Reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other G protein subunits and signal transduction targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P63218; product specifications from Assay Genie datasheets.
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