LGR6
LGR6 (leucine rich repeat containing G protein-coupled receptor 6) is a cell-surface receptor for R-spondins that potentiates canonical Wnt signalling. It is also known by the alias FLJ14471 and acts as a marker of multipotent stem cells in the epidermis. Browse Assay Genie's current range of LGR6 research reagents below, or read on for the biology behind the target.
LGR6 functions as a receptor for R-spondins and potentiates the canonical Wnt signalling pathway. After binding an R-spondin (RSPO1, RSPO2, RSPO3 or RSPO4), the receptor associates with phosphorylated LRP6 and with frizzled receptors that have been activated by extracellular Wnt ligands. This association triggers canonical Wnt signalling and increases expression of Wnt target genes. Unlike classical G protein-coupled receptors, LGR6 does not activate heterotrimeric G proteins to transduce its signal. It acts as a marker of multipotent stem cells in the epidermis, and it may act as a tumour suppressor.
The LGR6 gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily, and the protein belongs to the G protein-coupled receptor 1 family. It is a glycoprotein hormone receptor with a large N-terminal extracellular domain. The leucine-rich repeats in this domain are important for forming a horseshoe-shaped interaction motif for ligand binding. The protein localises to the cell membrane, and alternative splicing of the gene results in multiple transcript variants.
HGNC places LGR6 in the group of class A orphan G protein-coupled receptors. Its mouse ortholog is Lgr6. Researchers studying R-spondin signalling, Wnt pathway modulation and epidermal stem cell biology often examine LGR6 alongside its relatives LGR4 and LGR5.
LGR6 binds R-spondins and potentiates canonical Wnt signalling through association with LRP6 and frizzled receptors.
LGR6 is a marker of multipotent stem cells in the epidermis, making it relevant to studies of stem cell populations.
LGR6 transduces signals without activating heterotrimeric G proteins, which makes it a useful case for studying atypical receptor mechanisms.
LGR6 may act as a tumour suppressor, prompting investigation of its role in cancer-related signalling.
LGR6 is a receptor for R-spondins (RSPO1 to RSPO4). On binding, it associates with phosphorylated LRP6 and frizzled receptors to potentiate canonical Wnt signalling and raise target gene expression. It does not activate heterotrimeric G proteins, and it marks multipotent epidermal stem cells.
The alias FLJ14471 is listed for LGR6, and the UniProt name is leucine-rich repeat-containing G protein-coupled receptor 6. HGNC classes it among class A orphan G protein-coupled receptors. Alternative splicing of the gene produces multiple transcript variants.
A mouse ortholog, Lgr6, is recorded for the human gene. UniProt notes that LGR6 may act as a tumour suppressor, but no further disease associations are given here. Check the datasheet of any product for its validated reactivity.
Other leucine-rich repeat-containing GPCRs and R-spondin receptors involved in Wnt signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HBX8; product specifications from Assay Genie datasheets.