HTR4
HTR4 (5-hydroxytryptamine receptor 4, also known as 5-HT4) is a G protein-coupled receptor for serotonin. It couples to G(s) proteins, activates adenylate cyclase and stimulates cAMP production in the peripheral and central nervous system. Browse Assay Genie's current range of HTR4 research reagents below, or read on for the biology behind the target.
HTR4 is a receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that acts as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change in the receptor that triggers signalling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) alpha proteins and mediates activation of adenylate cyclase, so that serotonin binding leads to increased cAMP production.
The HTR4 gene encodes a glycosylated transmembrane protein that belongs to the G protein-coupled receptor 1 family. According to UniProt, the receptor is found at the cell membrane and at endosome membranes. It functions in both the peripheral and central nervous system, where it modulates the release of various neurotransmitters. The mouse and rat orthologs are both designated Htr4.
The gene is a member of the serotonin receptor family and sits in the HGNC group of 5-hydroxytryptamine receptors, G protein-coupled. Multiple transcript variants have been described, and they encode proteins with distinct C-terminal sequences. Earlier gene names were 5-hydroxytryptamine (serotonin) receptor 4 and 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled. Researchers studying serotonin signalling, cAMP-dependent pathways or neurotransmitter release will often work with the HTR4 protein and its variants alongside other serotonin receptor subtypes.
HTR4 transduces serotonin binding into G(s) coupling and adenylate cyclase activation, making it a model for studying receptor-driven cAMP production.
The receptor functions in the peripheral and central nervous system to modulate the release of various neurotransmitters.
HTR4 localises to the cell membrane and endosome membranes, relevant to work on GPCR activation and intracellular receptor location.
Multiple transcript variants encode proteins with distinct C-terminal sequences, which supports studies of isoform-specific receptor properties.
HTR4 is a G protein-coupled receptor for serotonin. On ligand binding it signals through G(s) alpha proteins, activates adenylate cyclase and raises cAMP production. It acts in the peripheral and central nervous system, where it modulates the release of various neurotransmitters.
HTR4 is also known as 5-HT4 and 5-hydroxytryptamine receptor 4. Earlier names included 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled. Multiple transcript variants have been described that encode proteins with distinct C-terminal sequences, so check the datasheet of any product for its validated reactivity.
Yes. Mouse and rat both have an ortholog designated Htr4. In humans, HTR4 belongs to the G protein-coupled receptor 1 family and to the HGNC group of G protein-coupled 5-hydroxytryptamine receptors, alongside other serotonin receptor subtypes.
Other serotonin receptor subtypes in the 5-hydroxytryptamine receptor gene group, studied alongside HTR4.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13639; product specifications from Assay Genie datasheets.