MAP2K3
MAP2K3 (mitogen-activated protein kinase kinase 3, also known as MEK3, MKK3, MAPKK3, SAPKK2 and PRKMK3) is a dual specificity kinase of the MAP kinase kinase family. It activates the MAP kinase p38 in response to cytokines and environmental stress. Browse Assay Genie's current range of MAP2K3 research reagents below, or read on for the biology behind the target.
MAP2K3 is a dual specificity kinase that catalyses the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38, which activates MAPK14. It is activated by cytokines and environmental stress in vivo, and by mitogenic stimuli, and it participates in the MAP kinase-mediated signalling cascade. One described cascade begins with activation of the adrenergic receptor ADRA1B and leads to activation of MAPK14. The kinase can also be activated by insulin and is necessary for the expression of the glucose transporter.
The MAP2K3 gene encodes a member of the protein kinase superfamily, belonging to the STE Ser/Thr protein kinase family and the MAP kinase kinase subfamily. HGNC places it in the group of mitogen-activated protein kinase kinases, and its enzyme classification is EC 2.7.12.2. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. The mouse ortholog is Map2k3. The protein is often referred to as MEK3 or MKK3, and the older names SAPKK2 and PRKMK3 appear in earlier literature.
MAP2K3 is relevant to cancer and infection biology. Expression of the RAS oncogene results in accumulation of the active form of this kinase, which leads to constitutive activation of MAPK14 and confers oncogenic transformation of primary cells. Inhibition of the kinase is involved in the pathogenesis of Yersinia pseudotuberculosis. These links make MAP2K3 a useful node for studying how stress and mitogenic signals are relayed to p38.
MAP2K3 is activated by cytokines and environmental stress, making it a key readout for how cells relay stress signals to p38 MAPK.
RAS oncogene expression causes active MAP2K3 to accumulate, driving constitutive MAPK14 activation and oncogenic transformation of primary cells.
MAP2K3 can be activated by insulin and is necessary for glucose transporter expression, linking it to metabolic signalling studies.
Inhibition of MAP2K3 is involved in the pathogenesis of Yersinia pseudotuberculosis, a point of interest for infection and immune signalling work.
MAP2K3 is a dual specificity kinase that phosphorylates a threonine and a tyrosine residue in the MAP kinase p38 (MAPK14), thereby activating it. It is activated by cytokines, mitogenic signals and environmental stress, and it can also be activated by insulin.
MAP2K3 is also called MEK3, MKK3, MAPKK3, SAPKK2 and PRKMK3, and its UniProt name is dual specificity mitogen-activated protein kinase kinase 3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for the gene.
RAS oncogene expression leads to accumulation of active MAP2K3 and constitutive MAPK14 activation, conferring oncogenic transformation of primary cells. Its inhibition features in Yersinia pseudotuberculosis pathogenesis. The mouse ortholog is Map2k3; check the datasheet of any product for its validated reactivity.
Other MAP kinase kinases, upstream MAP3K kinases and related signalling kinases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P46734; product specifications from Assay Genie datasheets.