CALM1
CALM1 (calmodulin 1, also known as CAMI, PHKD, DD132, PHKD1 and CALML2) is one of three calmodulin proteins encoded in the human genome. It is an EF-hand calcium-binding protein of the calmodulin family, linked to the regulation of cardiac ion channels. Browse Assay Genie's current range of CALM1 research reagents below, or read on for the biology behind the target.
CALM1 encodes one of three calmodulin proteins, members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels, placing the protein within calcium signalling in the heart. UniProt also records that calmodulin-1 is required for the arginine ADP-riboxanase activity of the bacterial effectors CopC from C. violaceum and OspC3 from S. flexneri during microbial infection.
Calmodulin-1 belongs to the calmodulin family. In UniProt its subcellular locations include the cytoplasmic cytoskeleton, specifically the spindle, the spindle pole and the centrosome (a microtubule organizing centre), as well as the flagellum of cell projections. The CALM1 gene has two pseudogenes, on chromosome 7 and on the X chromosome, and multiple transcript variants encoding different isoforms have been reported. The mouse and rat orthologues are both named Calm1.
HGNC places calmodulin 1 in the groups receptor ligands, EF-hand domain containing, phosphorylase kinase subunits and the UBR4 complex. The previous name, calmodulin 1 (phosphorylase kinase, delta), and the aliases PHKD and PHKD1 reflect its role as a phosphorylase kinase subunit. A missense mutation in the CALM1 gene has been associated with ventricular tachycardia, making it a gene of interest in cardiac arrhythmia research.
Calcium-activated calmodulin regulates and modulates the function of cardiac ion channels, so CALM1 is relevant to studies of cardiac electrophysiology.
A missense mutation in the CALM1 gene has been associated with ventricular tachycardia, making it a candidate in inherited arrhythmia research.
As an EF-hand calcium-binding protein of the calmodulin family, calmodulin-1 is a core component for studying calcium-dependent cellular signalling.
Calmodulin-1 is required for the arginine ADP-riboxanase activity of C. violaceum CopC and S. flexneri OspC3, linking it to bacterial effector research.
CALM1 encodes one of three calmodulin proteins, EF-hand calcium-binding proteins. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Calmodulin-1 is also required for the arginine ADP-riboxanase activity of the bacterial effectors CopC and OspC3 during infection.
CALM1 is also known as CAMI, PHKD, DD132, PHKD1 and CALML2. Its previous name was calmodulin 1 (phosphorylase kinase, delta). The UniProt protein name is calmodulin-1, and multiple transcript variants encoding different isoforms have been described for the gene.
A missense mutation in the CALM1 gene has been associated with ventricular tachycardia. Orthologues exist in mouse and rat, both named Calm1. Researchers should check the datasheet of any product for its validated reactivity.
Other calmodulin-like proteins and EF-hand calcium-binding family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P0DP23; product specifications from Assay Genie datasheets.