DNER
DNER (delta/notch like EGF repeat containing) is a cell-membrane protein that activates the NOTCH1 pathway and may mediate neuron-glia interaction during astrocytogenesis. It is also known as UNQ26 and bet. Browse Assay Genie's current range of DNER research reagents below, or read on for the biology behind the target.
DNER, the delta and Notch-like epidermal growth factor-related receptor, is an activator of the NOTCH1 pathway. UniProt annotates it as a protein that may mediate neuron-glia interaction during astrocytogenesis, placing it at the interface between developing neurons and glial cells. NCBI Gene describes it as predicted to enable Notch binding activity, consistent with a role in Notch-dependent signalling.
The DNER gene encodes a cell-membrane protein. According to NCBI Gene, the protein is located in dendrites, early endosomes and the plasma membrane, and the gene is involved in central nervous system development. These localisation data make DNER a useful subject for studies of membrane trafficking and cell-cell communication in neural tissue. Researchers investigating the DNER protein often do so alongside other components of Notch signalling.
The official HGNC name is delta/notch like EGF repeat containing, previously written delta/notch-like EGF repeat containing. The gene is also known by the aliases UNQ26 and bet. A mouse ortholog, Dner, is recognised, which allows the biology of this gene to be explored in rodent models of nervous system development.
DNER is an activator of the NOTCH1 pathway and is predicted to bind Notch, making it relevant to studies of Notch-dependent signalling.
DNER may mediate neuron-glia interaction during astrocytogenesis, so it is studied in the development and differentiation of astrocytes.
The DNER gene is involved in central nervous system development, supporting its use in research on how neural tissue forms.
DNER is found in dendrites, early endosomes and the plasma membrane, which makes it relevant to neuronal membrane trafficking research.
DNER is an activator of the NOTCH1 pathway. UniProt notes that it may mediate neuron-glia interaction during astrocytogenesis. NCBI Gene adds that it is predicted to enable Notch binding and is involved in central nervous system development.
The HGNC full name is delta/notch like EGF repeat containing, and UniProt calls the protein delta and Notch-like epidermal growth factor-related receptor. Aliases and previous symbols include UNQ26 and bet. The previous name was delta/notch-like EGF repeat containing.
A mouse ortholog, Dner, is recorded, so rodent models can be used to study its role in nervous system development. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Notch receptors, ligands and astrocyte markers relevant to DNER biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NFT8; product specifications from Assay Genie datasheets.