SIGLEC10
SIGLEC10 (sialic acid-binding Ig-like lectin 10, also known as SIGLEC-10, SLG2 and PRO940) is a cell-surface member of the SIGLEC family of the immunoglobulin superfamily. It binds sialic acids and acts as an inhibitory receptor in the immune response. Browse Assay Genie's current range of SIGLEC10 research reagents below, or read on for the biology behind the target.
SIGLEC10 is a putative adhesion molecule that mediates sialic acid-dependent binding to cells. It preferentially binds alpha-2,3- or alpha-2,6-linked sialic acid, and its recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response it appears to act as an inhibitory receptor: after ligand-induced tyrosine phosphorylation, it recruits cytoplasmic phosphatases through their SH2 domains, and these block signal transduction by dephosphorylating signalling molecules.
SIGLEC10 is involved in negative regulation of B-cell antigen receptor signalling, and the inhibition of B-cell activation depends on PTPN6/SHP-1. In association with CD24, it may contribute to the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90, and it may regulate natural killer (NK) cell responses. It also plays a role in the control of autoimmunity. In CD8-alpha(+) dendritic cells, it inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. This appears to involve recruitment of SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex and so promotes phagosomal acidification.
The SIGLEC10 protein belongs to the SIGLEC family of the immunoglobulin superfamily. SIGLECs are expressed on the cell surface, and most carry one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIMs). They are typically found on cells of the innate immune system. UniProt lists SIGLEC10 in both the cell membrane and secreted forms, and HGNC places the SIGLEC10 gene in the V-set and C2-set domain containing groups. The mouse ortholog is Siglec10.
SIGLEC10 acts as an inhibitory receptor that recruits SHP-1 and blocks signal transduction, making it a model for ITIM-dependent immune regulation.
SIGLEC10 negatively regulates B-cell antigen receptor signalling, and this inhibition depends on PTPN6/SHP-1.
With CD24, SIGLEC10 may selectively suppress responses to DAMPs such as HMGB1, HSP70 and HSP90, and may regulate NK cells.
SIGLEC10 helps control autoimmunity and limits cross-presentation by CD8-alpha(+) dendritic cells through SHP-1 and NADPH oxidase effects.
SIGLEC10 binds alpha-2,3- or alpha-2,6-linked sialic acid and acts as an inhibitory immune receptor. After tyrosine phosphorylation it recruits phosphatases such as SHP-1, which dampen signalling in B cells and other immune cells. It also helps control autoimmunity.
The HGNC name is sialic acid binding Ig like lectin 10. Aliases and previous symbols include SIGLEC-10, SLG2, PRO940 and MGC126774. UniProt uses the name Sialic acid-binding Ig-like lectin 10. Check the datasheet of any product for its validated reactivity.
SIGLEC10 is a member of the SIGLEC family within the immunoglobulin superfamily, alongside SIGLEC1, SIGLEC5, SIGLEC6, SIGLEC7, SIGLEC8 and SIGLEC9. A mouse ortholog, Siglec10, is recorded in the gene data.
Other SIGLEC family members and sialic acid-binding immune receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96LC7; product specifications from Assay Genie datasheets.