ANO1
ANO1 (anoctamin 1) is a calcium-activated chloride channel (CaCC) that shows increased sensitivity to intracellular Ca(2+). It is also known as TMEM16A, DOG1, ORAOV2 and TAOS2, and belongs to the anoctamin family. Browse Assay Genie's current range of ANO1 research reagents below, or read on for the biology behind the target.
ANO1 functions as a calcium-activated chloride channel (CaCC), and it shows increased sensitivity to intracellular Ca(2+). Its annotated molecular activity is monoatomic ion transmembrane transport, and it is involved in monoatomic anion transport. It also enables identical protein binding activity.
The ANO1 protein is assigned to the anoctamin family and sits in the HGNC Anoctamins gene group, alongside related proteins such as ANO2 and ANO6. UniProt places it at the apical cell membrane and at the presynapse, and NCBI Gene describes it as located in the apical plasma membrane. Beyond ion transport, the gene is described as involved in mucus secretion and in protein localisation to membrane, which makes the ANO1 gene a frequent subject in epithelial and secretory biology. The mouse ortholog is Ano1.
The target carries several names that reflect its history. Earlier names include oral cancer overexpressed 2 (ORAOV2), transmembrane protein 16A (TMEM16A) and anoctamin 1, calcium activated chloride channel, and DOG1 and TAOS2 are also listed as aliases. NCBI Gene reports that ANO1 is implicated in Moyamoya disease. Researchers working with the ANO1 protein, whether through an ANO1 antibody or an ANO1 ELISA kit, often use these alternative names when searching the literature.
ANO1 is a calcium-activated chloride channel with increased sensitivity to intracellular Ca(2+), making it a model for calcium-gated anion transport.
NCBI Gene links ANO1 to mucus secretion and places it in the apical plasma membrane, relevant to epithelial transport studies.
ANO1 is involved in protein localisation to membrane and is found at the apical cell membrane and presynapse.
ANO1 is implicated in Moyamoya disease, giving researchers a candidate gene for studies of this condition.
ANO1 is a calcium-activated chloride channel (CaCC) with increased sensitivity to intracellular Ca(2+). NCBI Gene also lists roles in monoatomic anion transport, mucus secretion and protein localisation to membrane, and describes it as located in the apical plasma membrane.
ANO1 is also called TMEM16A (transmembrane protein 16A), DOG1, ORAOV2 (oral cancer overexpressed 2), TAOS2 and FLJ10261. Its HGNC name is anoctamin 1, and an earlier name was anoctamin 1, calcium activated chloride channel.
NCBI Gene reports that ANO1 is implicated in Moyamoya disease. The mouse ortholog is Ano1. For work in a particular species, check the datasheet of any product for its validated reactivity.
Other anoctamin family members and related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5XXA6; product specifications from Assay Genie datasheets.