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SAMD4A
SAMD4A (sterile alpha motif domain containing 4A), also known as Smaug homolog 1, hSmaug1, SMGA or KIAA1053, is an RNA-binding protein of the SMAUG family. It acts as a translational repressor of messenger RNAs that contain Smaug recognition elements. Browse Assay Genie's current range of SAMD4A research reagents below, or read on for the biology behind the target.
SAMD4A functions as a translational repressor of messenger RNAs that contain Smaug recognition elements (SREs). According to the NCBI Gene summary, the sterile alpha motif (SAM) in proteins such as SAMD4A forms part of an RNA-binding domain. This domain acts as a posttranscriptional regulator by binding to the SRE, an RNA sequence motif. The motif takes its name from the Drosophila Smaug protein, and the SAMD4A protein belongs to the SMAUG family.
The human SAMD4A gene encodes a protein listed by UniProt as Protein Smaug homolog 1. HGNC places it in two gene groups: sterile alpha motif domain containing, and armadillo like helical domain containing. UniProt records the protein in the cytoplasm, and also in dendrites and synaptosomes. Mouse and rat each have an ortholog named Samd4a, so the protein can be studied in common rodent models.
The gene has carried several names. Earlier HGNC records list it as sterile alpha motif domain containing 4, with the symbol SAMD4, and the literature also uses KIAA1053, DKFZP434H0350, Smaug, SMG and SMGA. The name Smaug comes from the Drosophila protein that first defined the recognition element. Researchers working on SAMD4A often study posttranscriptional control, where RNA-binding proteins decide whether a given transcript is translated. Related SAM domain proteins, such as SAMD4B, share part of the nomenclature but are separate gene products.
SAMD4A acts as a translational repressor of SRE-containing messenger RNAs, making it a useful subject for studies of how translation is silenced.
Its SAM-containing RNA-binding domain regulates transcripts after transcription by binding the Smaug recognition element.
As a member of the SMAUG family, SAMD4A helps researchers compare how SAM-domain RNA-binding proteins recognise specific RNA motifs.
UniProt records SAMD4A in dendrites and synaptosomes as well as the cytoplasm, which points to roles in compartment-specific RNA regulation.
SAMD4A acts as a translational repressor of messenger RNAs that contain Smaug recognition elements (SREs). Its sterile alpha motif forms part of an RNA-binding domain, which allows it to regulate gene expression after transcription by binding the SRE sequence motif.
SAMD4A is also called Protein Smaug homolog 1, hSmaug1, Smaug, SMG, SMGA, SAMD4, KIAA1053 and DKFZP434H0350. HGNC previously named the gene sterile alpha motif domain containing 4. The Smaug name refers to the Drosophila protein.
Mouse and rat both have an ortholog named Samd4a. The name Smaug comes from the Drosophila Smaug protein, whose recognition element is bound by the SAM domain in SAMD4A. Check the datasheet of any product for its validated reactivity.
Other sterile alpha motif domain containing proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UPU9; product specifications from Assay Genie datasheets.
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