IFRD1
IFRD1 (interferon related developmental regulator 1) is an immediate early gene product related to interferon-gamma, also known as PC4 and TIS7. It is thought to regulate gene activity during cell growth and differentiation, including pathways induced by NGF. Browse Assay Genie's current range of IFRD1 research reagents below, or read on for the biology behind the target.
IFRD1 is encoded by an immediate early gene and is related to interferon-gamma. According to the NCBI Gene summary, the protein may act as a transcriptional co-activator or repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. UniProt annotates it more cautiously, noting that it could play a role in regulating gene activity in the proliferative and differentiative pathways induced by NGF, and that it may be an autocrine factor that attenuates or amplifies the initial ligand-induced signal.
The IFRD1 protein belongs to the IFRD family, and HGNC places the gene in the armadillo like helical domain containing group. The gene is also known by the aliases PC4 and TIS7. Alternate splicing of the IFRD1 gene results in multiple transcript variants. Mouse and rat orthologs, both named Ifrd1, are recognised, which allows the protein to be studied in common rodent models.
Mutations in the IFRD1 gene are associated with sensory/motor neuropathy with ataxia. The gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. These links, together with its role in differentiation, make IFRD1 a target of interest for researchers studying neural biology, tissue regeneration and airway disease. Researchers working with an IFRD1 antibody or IFRD1 ELISA kit are often investigating expression changes during growth and differentiation.
IFRD1 may control the growth and differentiation of specific cell types during embryonic development, making it relevant to studies of cell fate.
The gene is proposed to act in tissue regeneration, so IFRD1 is studied as a regulator of repair-related gene activity.
Mutations in IFRD1 are associated with sensory/motor neuropathy with ataxia, which supports its use in neurological disease research.
IFRD1 may modulate the pathogenesis of cystic fibrosis lung disease, giving it relevance in airway disease research.
IFRD1 is an immediate early gene product that may act as a transcriptional co-activator or repressor controlling growth and differentiation during development and tissue regeneration. UniProt suggests it could regulate gene activity in NGF-induced proliferative and differentiative pathways, and may attenuate or amplify the initial ligand-induced signal.
IFRD1 is the HGNC symbol for interferon related developmental regulator 1. The aliases PC4 and TIS7 are also used in the literature. UniProt lists the protein as interferon-related developmental regulator 1, and alternate splicing of the gene gives multiple transcript variants.
Mutations in IFRD1 are associated with sensory/motor neuropathy with ataxia, and the gene may modulate cystic fibrosis lung disease pathogenesis. Mouse and rat orthologs, both called Ifrd1, exist; check the datasheet of any product for its validated reactivity.
Interferon-related, neurotrophin and cystic fibrosis targets connected to IFRD1 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00458; product specifications from Assay Genie datasheets.