ITGA9
ITGA9 (integrin subunit alpha 9, also known as RLC, ITGA4L and ALPHA-RLC) encodes an alpha integrin subunit that mediates cell-cell and cell-matrix adhesion. Paired with the beta 1 chain, it forms a receptor for VCAM1, cytotactin and osteopontin. Browse Assay Genie's current range of ITGA9 research reagents below, or read on for the biology behind the target.
Integrins are heterodimeric integral membrane glycoproteins made up of an alpha chain and a beta chain, and they mediate cell-cell and cell-matrix adhesion. ITGA9 provides the alpha chain of the integrin alpha-9/beta-1 heterodimer (ITGA9:ITGB1). This complex acts as a receptor for VCAM1, cytotactin and osteopontin, and it recognises the sequence A-E-I-D-G-I-E-L in cytotactin.
ITGA9:ITGB1 has also been linked to SVEP1/polydom-mediated myoblast cell adhesion. In vascular smooth muscle cells, its interaction with SVEP1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity, thereby inhibiting vasocontraction.
The ITGA9 gene encodes the integrin alpha-9 protein, which belongs to the integrin alpha chain family and is found in the membrane. HGNC places it in the integrin alpha subunits gene group, and its previous name was integrin, alpha 9. The mouse ortholog is Itga9. Expression of the ITGA9 gene has been found to be upregulated in small cell lung cancers, which makes it a point of interest for researchers studying integrin biology in tumours.
ITGA9:ITGB1 mediates cell-matrix adhesion as a receptor for VCAM1, cytotactin and osteopontin, making it relevant to adhesion studies.
Through its interaction with SVEP1, ITGA9:ITGB1 inhibits vasocontraction by repressing calcium influx and calcium sensitivity in vascular smooth muscle cells.
ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion.
ITGA9 expression has been found to be upregulated in small cell lung cancers, supporting studies of integrin involvement in tumours.
ITGA9 is an integrin alpha subunit. With the beta 1 chain it forms a receptor for VCAM1, cytotactin and osteopontin, mediating cell adhesion. With SVEP1 in vascular smooth muscle cells, it inhibits vasocontraction by repressing calcium influx and ROCK-mediated calcium sensitivity.
ITGA9 is also called RLC, ITGA4L and ALPHA-RLC. Its full HGNC name is integrin subunit alpha 9, its UniProt name is integrin alpha-9, and its previous name was integrin, alpha 9. It functions as part of the ITGA9:ITGB1 heterodimer.
NCBI Gene reports that ITGA9 expression is upregulated in small cell lung cancers. A mouse ortholog, Itga9, is recorded. Check the datasheet of any product for its validated reactivity.
Other integrin alpha subunits involved in cell-cell and cell-matrix adhesion, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13797; product specifications from Assay Genie datasheets.