CRTAP
CRTAP (cartilage associated protein) is a secreted extracellular matrix protein of the leprecan family that is necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. It is also known as CASP, LEPREL3 and P3H5. Browse Assay Genie's current range of CRTAP research reagents below, or read on for the biology behind the target.
CRTAP is required for efficient 3-hydroxylation of prolyl residues in fibrillar collagen, a modification that contributes to the processing of collagen in connective tissue. The UniProt annotation describes it as necessary for this reaction rather than as an enzyme in its own right, and no EC number is assigned. The NCBI Gene summary describes the encoded protein as a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli.
The human CRTAP gene encodes a secreted protein found in the extracellular space and extracellular matrix. It belongs to the leprecan family and is classed by HGNC in the prolyl 3-hydroxylase family, which is reflected in the alias P3H5. The protein is similar to the chicken and mouse CRTAP genes, and the mouse ortholog is Crtap, so the mouse is a common system for studying its function.
The gene is also listed under the names CASP and LEPREL3. Defects in the CRTAP gene are associated with osteogenesis imperfecta, a connective tissue disorder characterised by bone fragility and low bone mass. This link makes CRTAP a frequent subject in studies of collagen biosynthesis, bone biology and heritable connective tissue disease. Researchers studying the CRTAP protein or gene often examine it alongside other members of the prolyl 3-hydroxylase family.
CRTAP is necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues, making it a key subject for studying collagen modification.
Defects in CRTAP are associated with osteogenesis imperfecta, a connective tissue disorder marked by bone fragility and low bone mass.
As a secreted protein of the extracellular matrix, CRTAP is relevant to studies of connective tissue composition and matrix assembly.
CRTAP may act as a scaffold influencing cytohesin/ARNO family activity in response to specific cellular stimuli.
CRTAP is necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. NCBI Gene also describes it as a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli.
CRTAP stands for cartilage associated protein. Its aliases and previous symbols are CASP, LEPREL3 and P3H5. UniProt lists it as cartilage-associated protein, and it belongs to the leprecan family, which HGNC groups with the prolyl 3-hydroxylase family.
Defects in CRTAP are associated with osteogenesis imperfecta, a connective tissue disorder with bone fragility and low bone mass. The protein is similar to chicken and mouse CRTAP, and the mouse ortholog is Crtap. Check the datasheet of any product for its validated reactivity.
Other prolyl 3-hydroxylase family members, collagen components and connective tissue markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75718; product specifications from Assay Genie datasheets.