TACC2 plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. It is involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors, and it may also play a role in organising centrosomal microtubules. The protein concentrates at centrosomes throughout the cell cycle, and UniProt annotates it in the cytoplasm, the nucleus and the centrosome, a microtubule organising centre.

The TACC2 gene encodes a member of the transforming acidic coiled-coil (TACC) family, a conserved group of centrosome- and microtubule-interacting proteins that are implicated in cancer. Several transcript variants encoding different isoforms have been described for the gene. The mouse ortholog is Tacc2, which allows the protein to be studied in murine models. Researchers working with the TACC2 protein or looking for a TACC2 antibody or TACC2 ELISA kit will often compare it with its family members TACC1 and TACC3.

TACC2 has attracted interest in cancer research. The gene lies within a chromosomal region associated with tumorigenesis, and the protein may act as a tumour suppressor and may represent a tumour progression marker. Expression of the gene is induced by erythropoietin and is thought to affect the progression of breast tumours. The names AZU-1 and ECTACC are alternative designations for the same gene, which HGNC lists under the TACC family.