P2RY12
P2RY12 (purinergic receptor P2Y12, also known as P2Y12, SP1999 and HORK3) is a G protein-coupled receptor for ADP and ATP. It signals through G proteins that inhibit adenylyl cyclase and is required for normal platelet aggregation and blood coagulation. Browse Assay Genie's current range of P2RY12 research reagents below, or read on for the biology behind the target.
P2RY12 is a receptor for the nucleotides ADP and ATP. It is coupled to G proteins that inhibit the adenylyl cyclase second messenger system, so receptor activation lowers adenylyl cyclase activity. It is not activated by UDP and UTP, which distinguishes its ligand preference from some other P2Y receptors. The receptor is required for normal platelet aggregation and blood coagulation, and this role underlies most of the research interest in the P2RY12 protein.
The P2RY12 gene encodes P2Y purinoceptor 12, a cell membrane protein of the G protein-coupled receptor 1 family. HGNC places it in the P2Y receptors gene group. This family has several receptor subtypes whose pharmacological selectivity differs and in some cases overlaps, for various adenosine and uridine nucleotides. Alternative splicing of the gene produces multiple transcript variants. Orthologues are annotated in mouse and rat, both named P2ry12, which allows the receptor to be studied in rodent models.
The receptor is involved in platelet aggregation and is regarded as a potential target for treating thromboembolisms and other clotting disorders. Mutations in the gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). The gene was previously named purinergic receptor P2Y, G-protein coupled, 12, and the symbols P2Y12, SP1999 and HORK3 appear in the literature. Researchers studying purinergic signalling, platelet function and haemostasis use P2RY12 as a reference target, including in work with a P2RY12 antibody or a P2RY12 ELISA kit.
P2RY12 is required for normal platelet aggregation, making it a central receptor for work on how ADP signalling drives platelet responses.
The receptor is a potential target for thromboembolisms and other clotting disorders, so it features in studies of blood coagulation.
Mutations in the gene are implicated in bleeding disorder, platelet type 8 (BDPLT8), linking the receptor to platelet-based bleeding phenotypes.
P2RY12 couples to G proteins that inhibit adenylyl cyclase, offering a model for nucleotide-responsive signalling among P2Y receptors.
P2RY12 is a receptor for ADP and ATP that couples to G proteins inhibiting the adenylyl cyclase second messenger system. It is not activated by UDP and UTP. The receptor is required for normal platelet aggregation and blood coagulation.
P2RY12 is the HGNC symbol for purinergic receptor P2Y12. Aliases include P2Y12, SP1999 and HORK3, and the UniProt name is P2Y purinoceptor 12. The previous name was purinergic receptor P2Y, G-protein coupled, 12. Alternative splicing gives multiple transcript variants.
Mutations in P2RY12 are implicated in bleeding disorder, platelet type 8 (BDPLT8). The receptor is a potential target for clotting disorders. Mouse and rat both carry a P2ry12 orthologue; check the datasheet of any product for its validated reactivity.
Other P2Y receptors, adenylyl cyclase pathway components and platelet function targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H244; product specifications from Assay Genie datasheets.