UBE2R2
UBE2R2 (ubiquitin conjugating enzyme E2 R2, also known as UBC3B and CDC34B) is an E2 ubiquitin-conjugating enzyme. It accepts ubiquitin from an E1 enzyme and, with an E3 ligase complex, catalyses its attachment to substrate proteins. Browse Assay Genie's current range of UBE2R2 research reagents below, or read on for the biology behind the target.
UBE2R2 is an E2 ubiquitin-conjugating enzyme. It accepts ubiquitin from an E1 ubiquitin-activating protein and catalyses its covalent attachment to other proteins, a step that depends on an E3 ubiquitin-protein ligase complex. In vitro, the enzyme catalyses both monoubiquitination and 'Lys-48'-linked polyubiquitination. It works in collaboration with various Cul1-RING and Cul2-RING E3 ligase complexes, and it may be involved in the degradation of catenin.
The human UBE2R2 gene encodes a protein that UniProt places in the ubiquitin-conjugating enzyme family. HGNC classifies it in the gene group of ubiquitin conjugating enzymes E2. The UBE2R2 protein is similar to the E2 enzyme UBC3/CDC34, which is reflected in its aliases UBC3B and CDC34B. Other names and symbols recorded for the gene include FLJ20419 and MGC10481, and its previous name was ubiquitin-conjugating enzyme E2R 2. The mouse ortholog is Ube2r2.
NCBI Gene links UBE2R2 to protein kinase CK2, a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme regulates beta-TrCP substrate recognition and induces its interaction with beta-TrCP. This enhances beta-catenin degradation. For researchers, UBE2R2 is a useful entry point for studying how E2 enzymes pair with cullin-RING ligases, and how phosphorylation can tune substrate selection in ubiquitin-dependent degradation. Work on the UBE2R2 gene, UBE2R2 protein and its activity can draw on this context.
UBE2R2 is an E2 enzyme that carries ubiquitin from E1 enzymes to E3 ligase complexes, making it relevant to ubiquitin conjugation mechanisms.
UBE2R2 collaborates with various Cul1-RING and Cul2-RING E3 ligase complexes, so it is studied in the context of these ligase assemblies.
In vitro, UBE2R2 catalyses monoubiquitination and 'Lys-48'-linked polyubiquitination, supporting work on how E2 enzymes shape ubiquitin modification.
Phosphorylation of UBE2R2 by CK2 is suggested to promote beta-TrCP interaction and enhance beta-catenin degradation.
UBE2R2 is an E2 ubiquitin-conjugating enzyme. It accepts ubiquitin from an E1 enzyme and, together with an E3 ligase complex, catalyses its attachment to other proteins. In vitro it mediates monoubiquitination and 'Lys-48'-linked polyubiquitination, and it works with Cul1-RING and Cul2-RING E3 complexes.
UBE2R2 is also called UBC3B and CDC34B, and the gene has been recorded as FLJ20419 and MGC10481. Its previous name was ubiquitin-conjugating enzyme E2R 2. The names UBC3B and CDC34B reflect its similarity to the E2 enzyme UBC3/CDC34.
UniProt notes that UBE2R2 may be involved in catenin degradation. NCBI Gene reports studies suggesting that CK2-dependent phosphorylation of UBE2R2 regulates beta-TrCP substrate recognition and induces their interaction, enhancing beta-catenin degradation. The mouse ortholog is Ube2r2; check the datasheet of any product for its validated reactivity.
Other ubiquitin-conjugating E2 enzymes and related ubiquitin pathway proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q712K3; product specifications from Assay Genie datasheets.