IL-3
IL-3 (interleukin 3, also known as MULTI-CSF and MCGF) is a secreted cytokine produced mainly by activated T-lymphocytes, mast cells and osteoblastic cells. It controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. Browse Assay Genie's current range of IL-3 research reagents below, or read on for the biology behind the target.
IL-3 is a potent growth-promoting cytokine that supports the proliferation of a broad range of haematopoietic cell types. It directs haematopoietic progenitor cells towards lineage-restricted fates and also activates mature basophils, eosinophils and monocytes. It is involved in cell growth, differentiation and apoptosis, and it has a role in neural cell proliferation and survival.
IL-3 acts through a receptor made up of the IL3RA subunit and a signal-transducing subunit, IL3RB. Receptor stimulation rapidly activates JAK2 kinase activity, which leads to a STAT5-mediated transcriptional programme. In non-haematopoietic systems, IL-3 can also contribute to cell survival under oxidative stress by activating PI3K/AKT and ERK-mediated pathways. In bone, it takes part in homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation.
The human IL3 gene encodes a secreted protein that belongs to the IL-3 family. HGNC places it in the interleukin and colony stimulating factor gene groups, and its previous name was interleukin 3 (colony-stimulating factor, multiple). Other aliases include MULTI-CSF and MCGF. NCBI Gene notes that the cytokine has neurotrophic activity and may be associated with neurologic disorders. Mouse and rat both carry an Il3 ortholog, so the IL-3 protein can be studied in common rodent models.
IL-3 controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells, making it a key factor for studying blood cell development.
IL-3 stimulates mature basophils, eosinophils and monocytes to become functionally activated, which makes it relevant to studies of these effector cells.
IL-3 plays a role in neural cell proliferation and survival, and it has neurotrophic activity that may be associated with neurologic disorders.
IL-3 takes part in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation.
IL-3 is a cytokine that controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. It also activates mature basophils, eosinophils and monocytes. It supports neural cell proliferation and survival and takes part in bone homeostasis, where it inhibits osteoclast differentiation.
IL-3 is encoded by the IL3 gene and is named interleukin 3 by HGNC. Aliases include MULTI-CSF and MCGF, with MGC79398 and MGC79399 as further listed symbols. The earlier name was interleukin 3 (colony-stimulating factor, multiple). UniProt records it as a secreted protein of the IL-3 family.
IL-3 signals through a receptor of IL3RA and the signal-transducing subunit IL3RB, which rapidly activates JAK2 and a STAT5-mediated transcriptional programme. Mouse and rat each have an Il3 ortholog. Check the datasheet of any product for its validated reactivity.
Other interleukins and cytokines involved in immune and haematopoietic signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P08700; product specifications from Assay Genie datasheets.