TPD52L2
TPD52L2 (TPD52 like 2) is a member of the tumour protein D52-like family, also known as D54, hD54 and TPD54. The protein carries an N-terminal coiled-coil motif that mediates assembly into homo- and heteromeric complexes with other family members. Browse Assay Genie's current range of TPD52L2 research reagents below, or read on for the biology behind the target.
TPD52L2 is a member of the tumour protein D52-like family. Proteins in this family are characterised by an N-terminal coiled-coil motif, which they use to form homo- and heteromeric complexes with other tumour protein D52-like proteins. This capacity for self-association and for pairing with relatives such as TPD52 is the main mechanistic feature described for the group, and it frames how the TPD52L2 protein is studied.
The human TPD52L2 gene encodes the protein recorded in UniProt as tumour protein D54, and it is also referred to as D54, hD54 and TPD54. The gene has previously been named tumour protein D52-like 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed, so researchers working with this target should consider which isoforms their experimental approach is likely to detect. A pseudogene of this gene is located on the long arm of chromosome 12, which is worth keeping in mind when designing nucleic acid-based assays.
In terms of disease relevance, expression of this gene may be a marker for breast cancer and acute lymphoblastic leukaemia. This association has made TPD52L2 a point of interest in cancer biology, although the available gene summary describes it as a possible marker rather than defining a mechanism. Mouse and rat orthologs, both named Tpd52l2, allow the gene to be examined in common rodent model systems.
Expression of the TPD52L2 gene may be a marker for breast cancer, making it a candidate for expression studies in this disease.
TPD52L2 expression may also be a marker for acute lymphoblastic leukaemia, supporting its investigation in haematological malignancy.
The N-terminal coiled-coil motif drives homo- and heteromeric complexes with other tumour protein D52-like proteins, a focus for interaction studies.
Alternatively spliced transcript variants encode multiple isoforms, so TPD52L2 is relevant to studies of transcript diversity and isoform-specific expression.
TPD52L2 belongs to the tumour protein D52-like family. Its characterised feature is an N-terminal coiled-coil motif used to form homo- and heteromeric complexes with other family proteins. Expression of the gene may also be a marker for breast cancer and acute lymphoblastic leukaemia.
TPD52L2 is also called D54, hD54 and TPD54, and UniProt lists the protein as tumour protein D54. Earlier names were tumour protein D52-like 2 and tumour protein D52 like 2. Alternatively spliced transcript variants encode multiple isoforms of the protein.
Yes, orthologs named Tpd52l2 exist in both mouse and rat, so the gene can be studied in rodent models. TPD52L2 is also linked to the TPD52 family, which includes TPD52. Check the datasheet of any product for its validated reactivity.
TPD52 family relatives and other targets studied alongside TPD52L2 in cancer biology, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43399; product specifications from Assay Genie datasheets.