GATA1
GATA1 (GATA binding protein 1, also known as GATA-1, ERYF1, NF-E1, NFE1 and GF1) is a nuclear transcription factor of the GATA family. It acts as a general switch factor for erythroid development, controlling genes expressed in erythroid cells. Browse Assay Genie's current range of GATA1 research reagents below, or read on for the biology behind the target.
GATA1 is a transcriptional activator or repressor that serves as a general switch factor for erythroid development. It binds DNA sites matching the consensus sequence 5'-[AT]GATA[AG]-3' within the regulatory regions of globin genes and of other genes expressed in erythroid cells. In studies of erythroid differentiation in K562 erythroleukaemia cells, GATA1 activates transcription of genes including HBB, HBG1/2, ALAS2 and HMBS.
The GATA1 gene encodes a member of the GATA family of transcription factors, classified by HGNC in the GATA zinc finger domain containing group. The protein is located in the nucleus, consistent with its role in regulating gene expression. It plays an important role in erythroid development by regulating the switch from foetal to adult haemoglobin. Orthologous genes, named Gata1, are present in mouse and rat.
The gene has appeared in the literature under several names, including globin transcription factor 1 (GF1), NF-E1 and ERYF1, reflecting its early identification through globin gene regulation. Mutations in GATA1 have been associated with X-linked dyserythropoietic anaemia and thrombocytopenia, which makes it a frequent subject in studies of erythroid and platelet-lineage disorders. Other GATA family members, such as GATA2 and GATA3, share the zinc finger DNA-binding architecture of the family but are studied in distinct contexts.
GATA1 is a general switch factor for erythroid development, making it a central protein for studying how erythroid gene programmes are established.
GATA1 helps regulate the switch from foetal to adult haemoglobin, linking it to globin gene regulation including HBB and HBG1/2.
Mutations in GATA1 are associated with X-linked dyserythropoietic anaemia and thrombocytopenia, so the protein is studied in inherited anaemia and platelet disorders.
GATA1 binds the 5'-[AT]GATA[AG]-3' motif and can activate or repress targets, providing a model for GATA-dependent gene control.
GATA1 is a transcriptional activator or repressor that acts as a general switch factor for erythroid development. It binds 5'-[AT]GATA[AG]-3' sites in globin genes and other erythroid-expressed genes, and activates genes such as HBB, HBG1/2, ALAS2 and HMBS during erythroid differentiation of K562 cells.
The HGNC name is GATA binding protein 1, and UniProt lists the protein as erythroid transcription factor. Aliases and previous symbols include GATA-1, ERYF1, NFE1, NF-E1 and GF1. Earlier names include GATA-binding protein 1 (globin transcription factor 1) and globin transcription factor 1.
Mutations in GATA1 have been associated with X-linked dyserythropoietic anaemia and thrombocytopenia. Mouse and rat both have an ortholog named Gata1. Check the datasheet of any product for its validated reactivity.
Other GATA family transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P15976; product specifications from Assay Genie datasheets.