Description
GATA1 Transcription Factor Activity Assay
The GATA1 Transcription Factor Activity Assay Kit is specifically designed for the precise measurement of GATA1 transcription factor activity in a variety of biological samples. With high sensitivity and accuracy, this kit provides researchers with reliable and reproducible results, making it an essential tool for studying the role of GATA1 in gene regulation and cellular processes.GATA1 is a key transcription factor that plays a critical role in the development and differentiation of blood cells, making it a crucial factor in hematopoiesis and erythropoiesis.
Dysregulation of GATA1 has been implicated in various hematologic disorders and other diseases, highlighting the importance of studying its activity and function.This assay kit is easy to use and suitable for a wide range of research applications, offering researchers a valuable tool for investigating the mechanisms underlying GATA1-mediated gene regulation and its impact on health and disease.
| Product Name: | GATA1 Transcription Factor Activity Assay |
| Product Code: | TFAB00114 |
| Target: | GATA1 |
| Synonyms: | Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 transcription factor activity protein |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie GATA1 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). |
| NCBI Summary: | This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15976 |
| NCBI GenInfo Identifier: | 120956 |
| NCBI Gene ID: | 2623 |
| NCBI Accession: | P15976.1 |
| UniProt Secondary Accession: | P15976,Q96GB8, |
| UniProt Related Accession: | P15976 |
| Molecular Weight: | 34,232 Da |
| NCBI Full Name: | Erythroid transcription factor |
| NCBI Synonym Full Names: | GATA binding protein 1 |
| NCBI Official Symbol: | GATA1 |
| NCBI Official Synonym Symbols: | GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1 |
| NCBI Protein Information: | erythroid transcription factor |
| UniProt Protein Name: | Erythroid transcription factor |
| UniProt Synonym Protein Names: | Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein |
| Protein Family: | GATA transcription factor |
| UniProt Gene Name: | GATA1 |
