OCT2 Transcription Factor Activity Assay

(No reviews yet) Write a Review
SKU:
TFAB00150
€599

Description

ELISA Kit Technical ManualMSDS

OCT2 Transcription Factor activity assay

Product Description:The ELISA Genie Oct2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates ELISA Genie ELISA kits are designed to significantly reduce experiment Time: and ensure sensitivity and flexibility for high-throughput screening.
Target Synonyms:Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2;Octamer-binding protein 2 Short name: Oct-2;Octamer-binding transcription factor 2 Short name: OTF-2
Detection Target:Phospho-IRAK1(Thr209)
Reactivity:Human, Mouse, Rat
Pack Size:12 x 8-Well Microstrips
Detection Method:Colorimetric 450 nm
Format:transcription factor activity assay
Storage and Stability Guarantee:4°C/6 Months
Sample Type:Nuclear or cell lysates
Range:See Technical Manual
Time:4.5 hours

OCT2 Transcription Factor activity assay Protein Information

UniProt Protein Function:Oct2: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class- 2 subfamily. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function:protein domain specific binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; immunoglobulin secretion during immune response; mature B cell differentiation; positive regulation of transcription, DNA-dependent; cell maturation; humoral immune response

NCBI Summary:The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:P09086
NCBI GenInfo Identifier:123402
NCBI Gene ID:5452
NCBI Accession:P09086.3
UniProt Secondary Accession:P09086,Q16648, Q7M4M8, Q9BRS4,
UniProt Related Accession:P09086
Molecular Weight:400
NCBI Full Name:POU domain, class 2, transcription factor 2
NCBI Synonym Full Names:POU class 2 homeobox 2
NCBI Official Symbol:POU2F2
NCBI Official Synonym Symbols:OCT2; OTF2; Oct-2
NCBI Protein Information:POU domain, class 2, transcription factor 2; OTF-2; homeobox protein; octamer-binding protein 2; octamer-binding transcription factor 2; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
UniProt Protein Name:POU domain, class 2, transcription factor 2
UniProt Synonym Protein Names:Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2; OTF-2
Protein Family:POU domain, class 2, transcription factor
UniProt Gene Name:POU2F2
UniProt Entry Name:PO2F2_HUMAN
View AllClose

0 Reviews

View AllClose