Biosimilar Antibodies

Biosimilar antibodies are copies of therapeutic antibodies with highly similar quality and efficacy that have been approved for medical use. Research-grade biosimilar antibodies offer a more readily available and cost effective alternative to the original antibody. and can serve as a reference antibody in the development of new biologics. Assay genie provides a range of high grade biosimilar antibodies produced under strict quality control processes to enable fast and cost effective research.

Features & Benefits

  • Research grade (RUO) biosimilar antibodies
  • Purified from cell supernatant by affinity chromatography
  • Antibodies are validated for target binding verification and off target effects by ELISA and flow cytometry to ensure quality and specificity
  • Demonstrated to be low or non-immunogenic

Applications

  • Ligand binding assays
  • Biologics development
  • Use as a reference antibody in pipeline drug development
  • In vivo Animal studies
  • Reference antibody in ELISA and flow cytometry
  • Studying of biochemical pathways

Biosimilar Antibodies

Product name Reactivity Host Clonality Application
Anti-4-1BB (Utomilumab) Antibody Human Homo sapiens Monoclonal ELISA
Anti-AXL (Enapotamab) Antibody Human Homo sapiens Monoclonal ELISA, Flow Cyt
Anti-B7-H3 (Enoblituzumab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-BAFF (Belimumab) Antibody Human Homo sapiens Monoclonal ELISA
Anti-BAFFR (Ianalumab) Antibody Human Homo sapiens Monoclonal ELISA, Flow Cyt
Anti-BCMA Antibody Human Humanized Monoclonal ELISA
Anti-BCMA (Belantamab) Antibody Human Humanized Monoclonal ELISA
Anti-CA9 (Girentuximab) Antibody Human Chimeric Monoclonal ELISA, Flow Cyt
Anti-CD123 (Talacotuzumab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-CD138 (Indatuximab ravtansine) Antibody Human Chimeric Monoclonal Flow Cyt
Anti-CD20 (Rituximab) Antibody Human Chimeric Monoclonal Flow Cyt
Anti-CD22 (Pinatuzumab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-CD27 (Varlilumab) Antibody Human Homo sapiens Monoclonal ELISA
Anti-CD30 (Brentuximab vedotin) Antibody Human Chimeric Monoclonal ELISA
Anti-CD33 (Gemtuzumab ozogamicin) Antibody Human Humanized Monoclonal Flow Cyt
Anti-CD37 (Naratuximab) Antibody Human Chimeric Monoclonal Flow Cyt
Anti-CD38 (Daratumumab) Antibody Human Homo sapiens Monoclonal ELISA, Flow Cyt
Anti-CD40 (Iscalimab)Antibody Human Homo sapiens Monoclonal ELISA
Anti-CD40L (Ruplizumab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-CD47 (Magrolimab) Antibody Human Homo sapiens Monoclonal ELISA, Flow Cyt
Anti-CD52 (Alemtuzumab) Antibody Human Humanized Monoclonal Flow Cyt
Anti-CD70 (Vorsetuzumab) Antibody Human Homo sapiens Monoclonal ELISA, Flow Cyt
Anti-CEACAM5 (Labetuzumab) Antibody Human Humanized Monoclonal ELISA
Anti-CS1 (Elotuzumab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-CTLA4 (Ipilimumab) Antibody Human Homo sapiens Monoclonal ELISA
Anti-EGFR (Cetuximab biosimilar) Antibody Human Chimeric Monoclonal ELISA
Anti-EPHA3 (Ifabotuzumab) Antibody Human Humanized Monoclonal ELISA
Anti-ICAM1 (Bersanlimab) Antibody Human Homo sapiens Monoclonal ELISA
Anti-ICOS (Vopratelimab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-IL17RA (Brodalumab) Antibody Human Homo sapiens Monoclonal ELISA, Flow Cyt
Anti-IL2RA (Basiliximab) Antibody Human Chimeric Monoclonal ELISA, Flow Cyt
Anti-IL6 (Siltuximab) Antibody Human Chimeric Monoclonal ELISA, Flow Cyt
Anti-IL6R (Tocilizumab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-Mesothelin (Amatuximab) Antibody Human Chimeric Monoclonal ELISA
Anti-NKG2D (Tesnatilimab) Antibody Human Homo sapiens Monoclonal ELISA
Anti-PD-1 (Pembrolizumab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-PDL1 (Atezolizumab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-TIGIT (Etigilimab) Antibody Human Humanized Monoclonal ELISA
Anti-TIGIT (Tiragolumab) Antibody Human Homo sapiens Monoclonal ELISA
Anti-TIGIT (Vibostolimab) Antibody Human Humanized Monoclonal ELISA
Anti-TIM3 (Cobolimab) Antibody Human Humanized Monoclonal ELISA, Flow Cyt
Anti-TNFRSF10B (Tigatuzumab) Antibody Human Humanized Monoclonal ELISA
Anti-Trop2 (Sacituzumab govitecan) Antibody Human Humanized Monoclonal ELISA
Anti-TweakR (Enavatuzumab) Antibody Human Humanized Monoclonal ELISA

Technology

Assay Genie’s biosimilar antibodies are produced using a revolutionary high throughput technology for monoclonal antibody development. Unlike hybridoma based monoclonal antibodies, this new technology can obtain IgG sequences from immunoreactive B cells directly with no need for hybridoma fusion. With no need for a hybridoma fusion, it will soon be possible to raise monoclonal antibodies from a range of animal species. Over 1000 immunoreactive B cells can be isolated from a single animal. Such high numbers means greater success in obtaining monoclonal antibodies with higher specificity, sensitivity and affinity. Directly obtaining the IgG sequences also means direct editing and optimisation of antibodies is possible for humanization.

Quality Control Data

Figure 1: ELISA plate precoated with 2 µg/ml Human CD47. Anti-CD47 (Magrolimab) biosimilar binds to Human CD47 and can be detected in a range of 0.061-1.606 ng/ml using a mFc-His tagged protein

Figure 2: HEK293 cells transfected with (A) human CD47 or (B) control protein. Cells were stained with 1 µg/ml anti-CD47 neutralising antibody (Magrolimab).

Related Tools for Research