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Anti-Phospho-GATA1-S310 Antibody (CABP0354)

SKU:
CABP0354
Product Type:
Antibody
Applications:
WB
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€329 - €419
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Description

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Antibody Name:Anti-Phospho-GATA1-S310 Antibody
Antibody SKU:CABP0354
Antibody Size:50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S310 of human GATA1
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:K-562
Immunogen:A phospho specific peptide corresponding to residues surrounding S310 of human GATA1
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2623
Uniprot:P15976
Cellular Location:Nucleus
Calculated MW:34kDa/35kDa/42kDa
Observed MW:43kDa
Anti-Phospho-GATA1-S310 Antibody (CABP0354)Western blot analysis of extracts from K-562 cells, using Phospho-GATA1-S310 antibody (CABP0354). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA.
Synonyms:GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT
Background:This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
UniProt Protein Function:Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781).
NCBI Summary:This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
UniProt Code:P15976
NCBI GenInfo Identifier:120956
NCBI Gene ID:2623
NCBI Accession:P15976.1
UniProt Secondary Accession:P15976,Q96GB8,
UniProt Related Accession:P15976
Molecular Weight:34,232 Da
NCBI Full Name:Erythroid transcription factor
NCBI Synonym Full Names:GATA binding protein 1
NCBI Official Symbol:GATA1  
NCBI Official Synonym Symbols:GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1  
NCBI Protein Information:erythroid transcription factor
UniProt Protein Name:Erythroid transcription factor
UniProt Synonym Protein Names:Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
Protein Family:GATA transcription factor
UniProt Gene Name:GATA1  

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