HEMGN
HEMGN (hemogen) is a nuclear protein that regulates the proliferation and differentiation of haematopoietic cells. It is also known as EDAG, CT155 and NDR, and is encoded by the HEMGN gene on chromosome 9. Browse Assay Genie's current range of HEMGN research reagents below, or read on for the biology behind the target.
HEMGN, or hemogen, regulates the proliferation and differentiation of haematopoietic cells. In the K562 cell model, overexpression of HEMGN blocks megakaryocytic differentiation induced by TPA, which points to a role in controlling lineage commitment in blood cell development. HEMGN may also help prevent apoptosis through activation of the nuclear factor-kappa B (NF-kB) pathway, although this is described in the annotation as a possible activity.
The human HEMGN protein is localised to the nucleus, and NCBI Gene reports it in the nucleoplasm. The HEMGN gene is located at 9q22.33 and is catalogued under HGNC:17509, NCBI Gene ID 55363 and UniProt Q9BXL5. Mouse and rat both carry an ortholog named Hemgn, which allows the gene to be studied in rodent systems. Researchers working on this target may look for a HEMGN antibody, a HEMGN ELISA kit or recombinant HEMGN protein to examine its expression and function.
The protein is known by several names: hemogen, EDAG, CT155 and NDR. Beyond blood cells, the NCBI Gene summary notes that HEMGN is predicted to be involved in the regulation of osteoblast differentiation, an annotation based on computational prediction rather than direct experiment. Together these data place HEMGN among nuclear factors that influence cell fate decisions, with haematopoietic differentiation as its best-described setting.
HEMGN regulates the proliferation and differentiation of haematopoietic cells, making it a relevant factor for studying blood cell lineage development.
Overexpression of HEMGN blocks TPA-induced megakaryocytic differentiation in K562 cells, providing a defined model for studying lineage control.
HEMGN may prevent apoptosis through activation of NF-kB, linking this nuclear protein to cell survival signalling.
HEMGN is predicted to be involved in regulating osteoblast differentiation, suggesting a possible role outside the blood lineage.
HEMGN regulates the proliferation and differentiation of haematopoietic cells. Overexpression blocks TPA-induced megakaryocytic differentiation in the K562 cell model, and it may also prevent apoptosis through activation of NF-kB. The protein is found in the nucleus.
HEMGN is the approved HGNC symbol for hemogen. Other names in use are EDAG, CT155 and NDR. The UniProt entry is Q9BXL5 and the NCBI Gene ID is 55363, which are useful when searching across databases.
Yes. Mouse and rat both have an ortholog named Hemgn, so the gene can be studied in rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Nuclear regulators and signalling factors linked to haematopoietic differentiation and cell survival.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BXL5; product specifications from Assay Genie datasheets.