CD66b
CD66b, encoded by the CEACAM8 gene and also known as CGM6, is a cell surface glycoprotein of the carcinoembryonic antigen (CEA) family. It mediates calcium-independent cell adhesion, including heterophilic interactions with other CEA-related adhesion molecules in activated neutrophils. Browse Assay Genie's current range of CD66b research reagents below, or read on for the biology behind the target.
CD66b is a cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. It mediates heterophilic cell adhesion, meaning that it binds to other, different carcinoembryonic antigen-related cell adhesion molecules rather than to itself. CEACAM6 is one such partner named in the UniProt annotation. This heterophilic interaction with CD66b occurs in activated neutrophils. Consistent with this, the NCBI Gene summary describes the protein as enabling protein heterodimerization activity and as involved in heterophilic cell-cell adhesion.
The protein is found in the cell membrane and at the cell surface. It belongs to the immunoglobulin superfamily and to the CEA family. In HGNC nomenclature it sits within the CD molecules, the V-set domain containing group and the CEA cell adhesion molecule family. Researchers studying the CD66b protein or the CEACAM8 gene will often consider it alongside related family members such as CEACAM1, CEACAM3, CEACAM6 and CEACAM7, which share the CEA family framework.
The official gene name is CEA cell adhesion molecule 8. Earlier names were carcinoembryonic antigen-related cell adhesion molecule 8, and the gene has also been known as CGM6. The CD66b designation reflects its place in the cluster of differentiation system. The NCBI Gene summary also lists CD66b as a biomarker of severe acute respiratory syndrome, which gives the protein relevance beyond basic adhesion biology.
CD66b engages in heterophilic adhesion that occurs in activated neutrophils, making it relevant to studies of how these cells change at the surface.
As a calcium-independent adhesion glycoprotein, CD66b is useful for studying heterophilic interactions within the CEA family, including with CEACAM6.
CD66b belongs to the immunoglobulin superfamily CEA family, so it supports comparative work across CEACAM members and their adhesion roles.
The NCBI Gene summary describes CD66b as a biomarker of severe acute respiratory syndrome, which motivates its use in biomarker research.
CD66b is a cell surface glycoprotein that mediates cell adhesion independently of calcium. It forms heterophilic interactions with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6, and this interaction occurs in activated neutrophils.
CD66b is the product of the CEACAM8 gene, named CEA cell adhesion molecule 8 by HGNC. It is also known as CGM6, and earlier names were carcinoembryonic antigen-related cell adhesion molecule 8. UniProt lists it as cell adhesion molecule CEACAM8.
The NCBI Gene summary lists CD66b as a biomarker of severe acute respiratory syndrome. The sources supplied do not describe other disease links. Ortholog information is not given here, so check the datasheet of any product for its validated reactivity.
Other CEA family adhesion molecules, including the CEACAM6 binding partner, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P31997; product specifications from Assay Genie datasheets.