AGTR2
AGTR2 (angiotensin II receptor type 2, also known as AT2 or MRX88) is a cell-membrane receptor for angiotensin II, a vasoconstricting peptide. It belongs to the G protein-coupled receptor 1 family and signals mainly through non-canonical pathways. Browse Assay Genie's current range of AGTR2 research reagents below, or read on for the biology behind the target.
AGTR2 is a receptor for angiotensin II, a vasoconstricting peptide. Unlike many family members, it primarily signals through non-canonical pathways that are independent of G proteins and beta-arrestin. It cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation, and it has been shown to mediate programmed cell death. This apoptotic function may be important in developmental biology and pathophysiology.
The AGTR2 gene encodes an integral membrane protein of the G protein-coupled receptor 1 family, and the protein sits at the cell membrane. According to the NCBI Gene summary, it is highly expressed in fetus and neonates but only scantily in adult tissues, with the exceptions of brain, adrenal medulla and atretic ovary. HGNC places it in the angiotensin receptors gene group, alongside AGTR1, and lists its previous name as angiotensin receptor 2.
Mutations in the AGTR2 gene have been associated with X-linked cognitive disability, which accounts for the MRX88 alias. The receptor has also drawn attention in coronavirus research. SARS-CoV and SARS-CoV-2 infection down-regulates angiotensin converting enzyme-2 (ACE2) receptors, and the serious inflammatory lesions that follow, mainly in the lungs, appear to be mediated by angiotensin II derivatives. These include signalling through the angiotensin AT2 receptor, which has been found upregulated in bronchoalveolar lavage samples from COVID-19 patients. Researchers studying AGTR2 often work alongside AGTR1, the other angiotensin II receptor.
AGTR2 is a receptor for angiotensin II and signals mainly through G protein- and beta-arrestin-independent routes, making it a focus for non-canonical GPCR signalling studies.
The receptor mediates programmed cell death, and its high foetal and neonatal expression points to roles in developmental biology and pathophysiology.
Mutations in AGTR2 are associated with X-linked cognitive disability, and the receptor is expressed in adult brain.
AT2 receptor expression is upregulated in bronchoalveolar lavage from COVID-19 patients, linking it to angiotensin-mediated inflammatory lesions in the lungs.
AGTR2 is a receptor for angiotensin II, a vasoconstricting peptide. It signals mainly through non-canonical, G protein- and beta-arrestin-independent pathways. It cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation, and it has been shown to mediate programmed cell death.
AGTR2 is the HGNC symbol for angiotensin II receptor type 2. It is also called AT2 and MRX88, the latter reflecting its link to X-linked cognitive disability. HGNC lists angiotensin receptor 2 as a previous name, and UniProt calls the protein Type-2 angiotensin II receptor.
Mouse and rat both have an Agtr2 ortholog. In humans, mutations in the AGTR2 gene are associated with X-linked cognitive disability, and the AT2 receptor is upregulated in bronchoalveolar lavage from COVID-19 patients. Check the datasheet of any product for its validated reactivity.
Other angiotensin receptors and renin-angiotensin pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P50052; product specifications from Assay Genie datasheets.