KLF5
KLF5 (KLF transcription factor 5, also known as IKLF, CKLF and BTEB2) is a nuclear C2H2-type zinc-finger transcription factor that binds GC box promoter elements and activates transcription of the genes it targets. It belongs to the Krueppel-like factor subfamily. Browse Assay Genie's current range of KLF5 research reagents below, or read on for the biology behind the target.
KLF5 is a transcription factor that binds to GC box promoter elements and activates the transcription of the genes that carry them. According to RefSeq, the encoded protein binds directly to a specific recognition motif in the promoters of its target genes, which makes it a transcriptional activator. It acts downstream of multiple different signalling pathways and is regulated by post-translational modification, so its activity can be adjusted by the signals a cell receives.
The KLF5 gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. UniProt places the protein in the Krueppel C2H2-type zinc-finger family, and HGNC lists it in the zinc fingers C2H2-type and KLF transcription factor gene groups. The protein is localised to the nucleus, consistent with its role in controlling gene expression. Alternative splicing of the KLF5 gene results in multiple transcript variants. The mouse ortholog is Klf5.
KLF5 may participate in both promoting and suppressing cell proliferation. Expression of the gene may be changed in a variety of different cancers and in cardiovascular disease, which is why the protein is of interest in studies of those conditions. The gene has carried several names over time: it was previously described as Kruppel-like factor 5 (intestinal), and the symbols IKLF, CKLF and BTEB2 are still found in the literature. Researchers studying KLF5 protein levels, expression or post-translational regulation will find these older names useful when searching earlier papers.
KLF5 binds GC box promoter elements and activates transcription, making it a model for studying how zinc-finger factors control target gene expression.
Expression of KLF5 may be changed in a variety of cancers, so it is studied as a factor linked to tumour cell behaviour.
Altered KLF5 expression has been reported in cardiovascular disease, prompting work on its role in the underlying gene regulation.
KLF5 acts downstream of multiple signalling pathways and may promote or suppress proliferation, with activity shaped by post-translational modification.
KLF5 is a transcriptional activator that binds GC box promoter elements and switches on the genes it targets. It acts downstream of multiple signalling pathways, is regulated by post-translational modification, and may participate in both promoting and suppressing cell proliferation.
KLF5 is also called IKLF, CKLF and BTEB2, and was previously named Kruppel-like factor 5 (intestinal). UniProt lists the protein as Krueppel-like factor 5. Alternative splicing of the gene produces multiple transcript variants.
Expression of the KLF5 gene may be changed in a variety of cancers and in cardiovascular disease. The mouse has an ortholog, Klf5, so the gene can be studied in that species; check the datasheet of any product for its validated reactivity.
Other KLF transcription factors and C2H2 zinc-finger family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13887; product specifications from Assay Genie datasheets.