CRX
CRX (cone-rod homeobox, also known as CRD, LCA7, OTX3 and CORD2) is a photoreceptor-specific transcription factor that drives gene expression in cone and rod cells. It is essential for the differentiation and maintenance of mammalian photoreceptors. Browse Assay Genie's current range of CRX research reagents below, or read on for the biology behind the target.
CRX is a transcription factor that binds and transactivates the DNA sequence 5'-TAATC[CA]-3'. This motif lies upstream of several photoreceptor-specific genes, including the opsin genes. CRX acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. It is essential for the maintenance of mammalian photoreceptors and is necessary for normal cone and rod function.
The CRX gene encodes a homeodomain protein that is localised to the nucleus. It belongs to the paired homeobox family and is classed by HGNC in the orthodenticle homeobox family. The protein is photoreceptor-specific and plays a role in the differentiation of photoreceptor cells. Several alternatively spliced transcript variants of the CRX gene have been described, although the full-length nature of some of them has not been determined. The mouse ortholog is Crx.
Mutations in CRX are associated with photoreceptor degeneration, Leber congenital amaurosis type III and autosomal dominant cone-rod dystrophy 2. These links explain the alternative names and symbols used for the gene, including LCA7, CORD2, CRD and OTX3. Researchers studying retinal development, photoreceptor gene regulation and inherited retinal disease use CRX as a key reference point, for example when examining CRX protein levels or CRX expression in experimental models.
CRX plays a role in the differentiation of photoreceptor cells, making it a central factor for studying how cone and rod identity is established.
CRX binds sequences upstream of photoreceptor-specific genes, including opsins, and cooperates with NRL, RORB and RAX to control their transcription.
Mutations in CRX are associated with Leber congenital amaurosis type III and autosomal dominant cone-rod dystrophy 2.
CRX is needed to maintain normal cone and rod function, so it is relevant to studies of photoreceptor degeneration.
CRX is a photoreceptor-specific transcription factor. It binds and transactivates the sequence 5'-TAATC[CA]-3' upstream of photoreceptor genes, including opsins, and works with NRL, RORB and RAX. It is essential for the maintenance of mammalian photoreceptors and normal cone and rod function.
CRX is also known as CRD, LCA7, OTX3 and CORD2, and its full name is cone-rod homeobox. Several alternatively spliced transcript variants have been described, although the full-length nature of some of these variants has not been determined.
Mutations in CRX are associated with photoreceptor degeneration, Leber congenital amaurosis type III and autosomal dominant cone-rod dystrophy 2. The mouse ortholog is Crx. Check the datasheet of any product for its validated reactivity.
Photoreceptor transcription factors, homeobox proteins and retinal markers related to CRX with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43186; product specifications from Assay Genie datasheets.