MNX1
MNX1 (motor neuron and pancreas homeobox 1, also known as HB9, HOXHB9, SCRA1 and HLXB9) is a nuclear homeobox transcription factor. It helps establish motor neuron identity and is involved in pancreas development and function. Browse Assay Genie's current range of MNX1 research reagents below, or read on for the biology behind the target.
MNX1 is a transcription factor that recognises and binds regulatory elements of target genes, negatively modulating their transcription. One named target is the visual system homeobox gene CHX10. In developing motor neurons, MNX1 acts together with the LIM domain transcription factor LMO4 to establish motor neuron identity. It also helps suppress interneuron genes in motor neurons, acting at least in part by blocking regulatory sequence interactions of the ISL1-LHX3 complex.
Beyond the nervous system, the MNX1 protein is involved in pancreas development and function, and it may play a role in pancreatic cell fate specification. The MNX1 gene encodes a nuclear protein that contains a homeobox domain. Alternatively spliced transcript variants encoding different isoforms have been reported for the gene. HGNC places it in the HOXL subclass of homeoboxes.
Mutations in the MNX1 gene result in Currarino syndrome, an autosomal dominant congenital malformation. The protein has appeared in the literature under several names, including HB9, HLXB9, HOXHB9 and SCRA1, and previously as homeo box HB9 or homeobox HB9. Orthologues are designated Mnx1 in both mouse and rat, so MNX1 can be studied in common rodent models.
MNX1 works with LMO4 to establish motor neuron identity, making it a key factor for studying how motor neuron fate is set.
MNX1 represses interneuron genes in motor neurons, partly by blocking ISL1-LHX3 complex regulatory interactions, so it is relevant to studies of neuronal subtype gene control.
MNX1 is involved in pancreas development and function and may contribute to pancreatic cell fate specification.
Mutations in MNX1 cause Currarino syndrome, an autosomal dominant congenital malformation, linking the gene to developmental disease studies.
MNX1 is a nuclear transcription factor that binds regulatory elements of target genes and negatively modulates transcription. It helps establish motor neuron identity with LMO4, represses interneuron genes in motor neurons, and is involved in pancreas development and function.
MNX1 is also called HB9, HOXHB9, SCRA1 and HLXB9, and was previously named homeo box HB9 or homeobox HB9. NCBI Gene reports alternatively spliced transcript variants that encode different isoforms, so check which isoform your work requires.
Mutations in the MNX1 gene result in Currarino syndrome, an autosomal dominant congenital malformation. Mouse and rat both carry an orthologous gene named Mnx1. Check the datasheet of any product for its validated reactivity.
Transcription factor partners and target genes involved in motor neuron specification, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P50219; product specifications from Assay Genie datasheets.