DPEP2
DPEP2 (dipeptidase 2) is a membrane-bound dipeptidase of the M19 metallopeptidase group that hydrolyses a range of dipeptides. Independently of this enzymatic activity, it can also modulate the macrophage inflammatory response through the NF-kappaB signalling pathway. Browse Assay Genie's current range of DPEP2 research reagents below, or read on for the biology behind the target.
DPEP2 belongs to the membrane-bound dipeptidase family (EC 3.4.13.19). These enzymes hydrolyse a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly), which is formed during glutathione degradation. The DPEP2 protein therefore sits at the interface of peptide catabolism and lipid mediator metabolism.
Beyond its catalytic role, UniProt annotates a function for DPEP2 that is independent of its dipeptidase activity: it can modulate the macrophage inflammatory response by acting as a regulator of the NF-kappaB inflammatory signalling pathway. This makes it of interest to researchers studying how enzymes of the innate immune system can also act as signalling regulators.
The DPEP2 gene encodes a protein of the metallo-dependent hydrolases superfamily and the peptidase M19 family, classified by HGNC within the M19 metallopeptidases. It is a membrane protein. Related members of the group include DPEP1 and DPEP3, and mouse and rat orthologs of the gene are both named Dpep2, which allows comparative work in rodent models.
DPEP2 can regulate NF-kappaB signalling in macrophages, making it a candidate for studying inflammatory response control.
Membrane dipeptidases such as DPEP2 hydrolyse leukotriene D4, linking the enzyme to the processing of this lipid mediator.
DPEP2 hydrolyses cystinyl-bis-glycine formed during glutathione breakdown, supporting work on glutathione catabolism.
Family members cleave the beta-lactam ring of some antibiotics, a feature relevant to studies of dipeptidase substrate range.
DPEP2 is a membrane-bound dipeptidase that hydrolyses dipeptides, including leukotriene D4 and cystinyl-bis-glycine from glutathione degradation. Independently of this activity, it can also regulate NF-kappaB inflammatory signalling and so modulate the macrophage inflammatory response.
DPEP2 (dipeptidase 2) is classed by HGNC in the M19 metallopeptidases and by UniProt in the metallo-dependent hydrolases superfamily, peptidase M19 family. Its enzyme classification is EC 3.4.13.19. DPEP1 and DPEP3 are related dipeptidases.
Yes. Mouse and rat both have an ortholog named Dpep2, so the gene can be studied in rodent models. Check the datasheet of any product for its validated reactivity.
Other members of the M19 dipeptidase group that are related to DPEP2.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H4A9; product specifications from Assay Genie datasheets.