MFGE8
MFGE8 (milk fat globule EGF and factor V/VIII domain containing), also known as lactadherin, SED1, EDIL1 and MFG-E8, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. Its cleavage product, medin, is the major component of aortic medial amyloid. Browse Assay Genie's current range of MFGE8 research reagents below, or read on for the biology behind the target.
The major protein product of the MFGE8 gene is lactadherin, a membrane glycoprotein that promotes the phagocytosis of apoptotic cells. By supporting the clearance of dying cells, it has been linked to several biological settings. NCBI Gene reports that the protein has been implicated in wound healing, autoimmune disease and cancer, which makes the MFGE8 protein a frequent subject in studies of cell clearance and inflammation.
The gene encodes a preproprotein that is proteolytically processed into multiple protein products. Lactadherin can be cleaved further to give a smaller fragment, medin, which is the major protein component of aortic medial amyloid (AMA). UniProt annotates the protein as the main constituent of this amyloid, so MFGE8 is relevant to work on vascular amyloid deposition. Alternative splicing of the gene produces multiple transcript variants.
UniProt lists lactadherin in the membrane and secreted fractions, and in the acrosome membrane of secretory vesicles in the cytoplasm. The protein has accumulated many names. Previous gene names include sperm associated antigen 10 and milk fat globule-EGF factor 8 protein, and the aliases SED1, EDIL1, BA46, OAcGD3S, HsT19888, MFG-E8, hP47 and SPAG10 appear in the literature. The mouse and rat orthologs are both named Mfge8.
Lactadherin promotes phagocytosis of apoptotic cells, so MFGE8 is studied in the mechanisms by which dying cells are removed.
NCBI Gene reports that MFGE8 has been implicated in wound healing, making it a target in tissue repair research.
MFGE8 has been implicated in autoimmune disease and cancer, and is examined in studies of both.
Medin, a lactadherin cleavage product, is the major component of aortic medial amyloid, linking MFGE8 to amyloid biology.
MFGE8 encodes lactadherin, a membrane glycoprotein that promotes phagocytosis of apoptotic cells. It has also been implicated in wound healing, autoimmune disease and cancer. A smaller cleavage product, medin, is the major protein component of aortic medial amyloid.
MFGE8 is also called lactadherin, SED1, EDIL1, BA46, OAcGD3S, HsT19888, MFG-E8, hP47 and SPAG10. Earlier names were sperm associated antigen 10 and milk fat globule-EGF factor 8 protein. Alternative splicing gives multiple transcript variants, and the preproprotein is processed into several products.
Lactadherin has been implicated in autoimmune disease, cancer and wound healing, and its fragment medin is the main component of aortic medial amyloid. Orthologs named Mfge8 exist in mouse and rat; check the datasheet of any product for its validated reactivity.
Related targets in apoptosis, phagocytosis and amyloid research with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q08431; product specifications from Assay Genie datasheets.