VLDLR
VLDLR (very low density lipoprotein receptor) is a cell surface member of the low density lipoprotein receptor family, involved in receptor-mediated endocytosis of specific ligands. It contributes to VLDL-triglyceride metabolism and the reelin signalling pathway, and is also known as CARMQ1, CHRMQ1 and VLDLRCH. Browse Assay Genie's current range of VLDLR research reagents below, or read on for the biology behind the target.
VLDLR belongs to the low density lipoprotein receptor (LDLR) gene family, a group of cell surface proteins that mediate receptor-mediated endocytosis of specific ligands. The VLDLR protein is found at the cell membrane and in clathrin-coated pits, the sites from which bound ligands are internalised. It plays important roles in VLDL-triglyceride metabolism and in the reelin signalling pathway.
The VLDLR gene encodes a lipoprotein receptor of the LDLR family, and alternative splicing generates multiple transcript variants that encode distinct isoforms. Researchers working with the VLDLR protein should therefore consider which isoform is relevant to their question. HGNC classifies the gene within the low density lipoprotein receptors group. Orthologous genes, named Vldlr, are present in both mouse and rat, which supports work in rodent models.
Mutations in the VLDLR gene cause VLDLR-associated cerebellar hypoplasia, linking the receptor to cerebellar development through the reelin pathway. The aliases CARMQ1, CHRMQ1 and VLDLRCH reflect this disease association. In addition to its roles in lipid handling and neurodevelopmental signalling, VLDLR functions as a receptor for yellow fever virus, making it relevant to studies of viral entry.
VLDLR is involved in VLDL-triglyceride metabolism, making it a focus for studies of lipoprotein handling and receptor-mediated uptake.
The receptor takes part in the reelin signalling pathway, which is central to work on how this pathway is transduced at the cell surface.
Mutations in VLDLR cause VLDLR-associated cerebellar hypoplasia, so the gene is studied in cerebellar development and related disorders.
VLDLR functions as a receptor for yellow fever virus, supporting research into host receptors used during flavivirus infection.
VLDLR is a cell surface lipoprotein receptor of the LDLR family that mediates receptor-mediated endocytosis of specific ligands. It plays important roles in VLDL-triglyceride metabolism and the reelin signalling pathway, and it also acts as a receptor for yellow fever virus.
VLDLR is also known as CARMQ1, CHRMQ1 and VLDLRCH, and its full name is very low density lipoprotein receptor. Alternative splicing of the VLDLR gene generates multiple transcript variants that encode distinct isoforms.
Mutations in VLDLR cause VLDLR-associated cerebellar hypoplasia. The receptor is also used by yellow fever virus. Mouse and rat both carry a Vldlr ortholog; check the datasheet of any product for its validated reactivity.
Other LDLR family receptors, reelin pathway components and lipid metabolism targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P98155; product specifications from Assay Genie datasheets.