RXRB
RXRB (retinoid X receptor beta) is a nuclear hormone receptor that acts as a receptor for retinoic acid and regulates gene expression by binding DNA response elements as a dimer. It is also known as NR2B2, H-2RIIBP, RCoR-1 and RXR-beta. Browse Assay Genie's current range of RXRB research reagents below, or read on for the biology behind the target.
RXRB is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and in this way regulate gene expression in a range of biological processes. The RAR/RXR heterodimers recognise the retinoic acid response elements (RARE) in target genes. The RXRB protein is therefore a ligand-regulated transcription factor that links retinoid signals to changes in gene transcription.
The RXRB gene encodes a member of the retinoid X receptor (RXR) family, which is involved in mediating the effects of retinoic acid. According to the NCBI Gene summary, the encoded protein forms dimers with the retinoic acid, thyroid hormone and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. UniProt places the protein in the nuclear hormone receptor family, NR2 subfamily, and records it in both the nucleus and the cytoplasm. The human gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6, and alternatively spliced transcript variants encoding multiple isoforms have been observed. Mouse and rat each carry an orthologous gene, Rxrb.
The protein is listed by UniProt as retinoic acid receptor RXR-beta, and HGNC classifies it in the retinoid X receptors gene group. HGNC records the previous name as retinoid X receptor, beta. Other symbols found in the literature include NR2B2, H-2RIIBP, RCoR-1 and RXRbeta, so it is worth searching under several names when reviewing earlier work on this receptor.
RXRB is a receptor for retinoic acid and mediates its effects through binding to response elements in target genes.
The protein dimerises with retinoic acid, thyroid hormone and vitamin D receptors, increasing DNA binding and transcriptional function.
RAR/RXR heterodimers bind retinoic acid response elements to regulate gene expression in various biological processes.
The RXRB gene sits within the MHC class II region on chromosome 6, and its transcripts undergo alternative splicing.
RXRB is a receptor for retinoic acid. It binds as a heterodimer, for example with retinoic acid receptors, to response elements in DNA in response to all-trans or 9-cis retinoic acid, and so regulates gene expression in various biological processes.
RXRB is also called NR2B2, H-2RIIBP, RCoR-1, RXRbeta and RXR-beta, and was previously named retinoid X receptor, beta. NCBI reports that alternatively spliced transcript variants encoding multiple isoforms have been observed for the gene.
Mouse and rat both have an orthologous gene named Rxrb, which allows work on the receptor in rodent models. Reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other retinoid X receptors, retinoic acid receptors and nuclear receptor partners that dimerise with RXRB.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P28702; product specifications from Assay Genie datasheets.