HNRNPU
HNRNPU (heterogeneous nuclear ribonucleoprotein U), also known as SAF-A, is a nucleic acid-binding protein that helps form ribonucleoprotein complexes with heterogeneous nuclear RNA in the nucleus. It binds both RNA and DNA, including scaffold-attached region DNA. Browse Assay Genie's current range of HNRNPU research reagents below, or read on for the biology behind the target.
HNRNPU belongs to the family of heterogeneous nuclear ribonucleoproteins, which bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The protein has affinity for both RNA and DNA and binds scaffold-attached region (SAR) DNA, which is the origin of its alternative name, scaffold attachment factor A (SAF-A). In the context of HIV-1 infection, UniProt annotates HNRNPU as a negative regulator of viral replication: it prevents the accumulation of viral mRNA transcripts in the cytoplasm.
UniProt records HNRNPU in many cellular compartments. It is found in the nucleus, nuclear matrix, nuclear speckles and on chromosomes. It is also found at the centrosome, the kinetochore at the centromere, the spindle and spindle pole, and the midbody. Further locations include the cytoplasm, cytoplasmic granules and the cell surface. This spread of locations suggests the protein is associated with several structures during interphase and cell division. Any HNRNPU antibody, HNRNPU protein or HNRNPU ELISA kit used in the lab should be chosen with the intended compartment and sample in mind.
The HNRNPU gene is in the HGNC group of heterogeneous nuclear ribonucleoproteins. Earlier names and symbols include HNRPU, C1orf199, NCRNA00201 and HNRNPU antisense RNA 1, and a previous name was heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A). Mutations in the HNRNPU gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of the gene has been identified on chromosome 14. Mouse and rat both have an ortholog named Hnrnpu.
HNRNPU binds nucleic acids and takes part in forming ribonucleoprotein complexes with hnRNA in the nucleus.
The protein binds scaffold-attached region DNA and localises to the nuclear matrix and chromosomes.
Mutations in HNRNPU are associated with early infantile epileptic encephalopathy 54.
HNRNPU negatively regulates HIV-1 replication by preventing viral mRNA transcripts from accumulating in the cytoplasm.
HNRNPU binds both RNA and DNA and functions in forming ribonucleoprotein complexes with heterogeneous nuclear RNA in the nucleus. It also binds scaffold-attached region DNA. During HIV-1 infection it limits replication by preventing viral mRNA transcripts from accumulating in the cytoplasm.
Aliases and previous symbols include SAF-A, HNRPU, FLJ37978, FLJ30202, HNRNPU-AS1, C1orf199 and NCRNA00201. The name scaffold attachment factor A refers to its binding of scaffold-attached region DNA. Check the datasheet of any product for its validated reactivity.
Mutations in the HNRNPU gene have been associated with epileptic encephalopathy, early infantile, 54. Mouse and rat each have an ortholog called Hnrnpu. A pseudogene of the human gene has been identified on chromosome 14. Check the datasheet of any product for its validated reactivity.
Related heterogeneous nuclear ribonucleoproteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q00839; product specifications from Assay Genie datasheets.