SCPEP1
SCPEP1 (serine carboxypeptidase 1, also known as RISC) is a secreted serine carboxypeptidase of the peptidase S10 family. It is thought to be involved in vascular wall and kidney homeostasis. Browse Assay Genie's current range of SCPEP1 research reagents below, or read on for the biology behind the target.
SCPEP1, the retinoid-inducible serine carboxypeptidase, is predicted to enable serine-type carboxypeptidase activity, meaning it is expected to remove amino acids from the C-terminal end of peptide substrates. UniProt annotates it as a protein that may be involved in vascular wall and kidney homeostasis, and the protein is classed as secreted. NCBI Gene also reports its location in the extracellular exosome.
The SCPEP1 gene encodes a protein that belongs to the peptidase S10 family and is listed by HGNC within the M14 carboxypeptidases gene group. The enzyme carries the EC designation 3.4.16.-. Its alternative name, RISC, reflects the retinoid-inducible serine carboxypeptidase description used by UniProt. Orthologues are annotated in both mouse and rat, each named Scpep1, which allows the gene to be studied in common rodent models.
Based on predictions from the Alliance of Genome Resources, SCPEP1 is involved in the negative regulation of blood pressure and in retinoic acid metabolic processes. It is also predicted to act upstream of or within the maintenance of blood vessel diameter. These annotations are predictions rather than established mechanisms, so researchers studying the SCPEP1 protein should treat its precise substrates and physiological roles as open questions.
SCPEP1 may be involved in vascular wall homeostasis and is predicted to act in the maintenance of blood vessel diameter.
SCPEP1 is predicted to be involved in the negative regulation of blood pressure, making it a candidate for cardiovascular studies.
UniProt notes that SCPEP1 may be involved in kidney homeostasis, which makes it relevant to studies of renal physiology.
SCPEP1 is predicted to participate in retinoic acid metabolic processes, consistent with its designation as a retinoid-inducible carboxypeptidase.
SCPEP1 is predicted to act as a serine-type carboxypeptidase. UniProt states it may be involved in vascular wall and kidney homeostasis. NCBI Gene also predicts roles in negative regulation of blood pressure, retinoic acid metabolic processes and maintenance of blood vessel diameter.
The HGNC name is serine carboxypeptidase 1, and UniProt lists the protein as retinoid-inducible serine carboxypeptidase. The alias RISC derives from that name. HGNC groups the gene with the M14 carboxypeptidases, while UniProt places the protein in the peptidase S10 family.
Yes. Mouse and rat orthologues are both annotated as Scpep1. Researchers working in rodent models can therefore study the gene in these species; check the datasheet of any product for its validated reactivity.
Other carboxypeptidases, serine peptidases and cardiovascular and renal pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HB40; product specifications from Assay Genie datasheets.