UPRT
UPRT (uracil phosphoribosyltransferase homolog) is a member of the UPRTase family that catalyses the conversion of uracil to uridine monophosphate in the pyrimidine salvage pathway. It is also known as FUR1, DKFZp781E1243 and MGC23937. Browse Assay Genie's current range of UPRT research reagents below, or read on for the biology behind the target.
UPRT encodes uracil phosphoribosyltransferase, an enzyme that catalyses the reaction of uracil with 5-phosphoribosyl-1-R-diphosphate to give uridine monophosphate (UMP). This reaction forms an important part of nucleotide metabolism, and specifically of the pyrimidine salvage pathway, in which free bases are recycled into nucleotides rather than being synthesised from scratch. Researchers studying this pathway may look at the UPRT protein as a representative salvage enzyme.
The enzyme localises to both the nucleus and the cytoplasm. It belongs to the UPRTase family. The human UPRT gene sits on the X chromosome, and a mouse ortholog, Uprt, has been identified, which allows comparative work between species. Researchers who use a UPRT antibody or a UPRT ELISA kit should check the datasheet of each product for its validated reactivity.
The gene was previously named uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae), a reference to the yeast FUR1 gene, and FUR1 is still listed among its aliases. Other aliases include DKFZp781E1243, MGC23937 and RP11-311P8.3. UPRT is regarded as a potential target for the rational design of drugs to treat parasitic infections and cancer, which makes it of interest in both nucleotide metabolism and therapeutic research.
UPRT converts uracil and 5-phosphoribosyl-1-R-diphosphate to UMP, so it is a useful enzyme for studying nucleotide metabolism.
The enzyme acts in the pyrimidine salvage pathway, making it relevant to work on how cells recycle free bases into nucleotides.
UPRT is described as a potential target for the rational design of drugs to treat cancer.
The protein is also considered a potential target for rational drug design against parasitic infections.
UPRT encodes uracil phosphoribosyltransferase, which catalyses the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This step is part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme is found in the nucleus and cytoplasm.
The HGNC name is uracil phosphoribosyltransferase homolog. Aliases and previous symbols include FUR1, DKFZp781E1243, MGC23937 and RP11-311P8.3. The earlier gene name was uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae), which refers to the yeast gene.
The NCBI Gene summary describes UPRT as a potential target for the rational design of drugs to treat parasitic infections and cancer. A mouse ortholog, Uprt, exists. Check the datasheet of any product for its validated reactivity.
Other pyrimidine salvage and nucleotide-metabolism enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96BW1; product specifications from Assay Genie datasheets.