SCARF2
SCARF2 (scavenger receptor class F member 2, also known as SREC-II, SREC2 and HUMZD58C02) is a membrane protein of the scavenger receptor group. It is a probable adhesion protein that mediates homophilic and heterophilic interactions. Browse Assay Genie's current range of SCARF2 research reagents below, or read on for the biology behind the target.
SCARF2 is a probable adhesion protein that mediates both homophilic and heterophilic interactions. It is classed with the scavenger receptors, yet it behaves differently from its better-known relative SCARF1. Where SCARF1 mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL), SCARF2 does so only poorly. It has little activity in internalising modified low density lipoproteins (LDL).
The protein encoded by the SCARF2 gene is similar to SCARF1, also called SREC-I. It can interact with SCARF1 through its extracellular domain. This association is suppressed when scavenger ligands are present, which suggests that ligand binding and receptor pairing are linked. UniProt lists the protein as a membrane protein. RefSeq reports alternatively spliced transcript variants that encode distinct isoforms.
The gene is symbolised SCARF2 and sits in the HGNC scavenger receptors group. Its approved name is scavenger receptor class F member 2, and its previous name was scavenger receptor class F, member 2. Other names in use include SREC-II, SREC2 and HUMZD58C02. The mouse ortholog is Scarf2. Researchers studying SCARF2 often compare it with SCARF1 to separate adhesion-related activity from lipoprotein scavenging within the class F receptors.
SCARF2 is a probable adhesion protein that mediates homophilic and heterophilic interactions, making it a candidate for studies of cell-cell contact.
SCARF2 poorly mediates Ac-LDL binding and degradation compared with SCARF1, which makes it useful for contrasting class F receptor functions.
SCARF2 interacts with SCARF1 through its extracellular domain, and scavenger ligands suppress this association.
SCARF2 has only little activity in internalising modified LDL, providing a reference point for work on lipoprotein handling by scavenger receptors.
SCARF2 is a probable adhesion protein that mediates homophilic and heterophilic interactions. Unlike SCARF1, it poorly mediates the binding and degradation of acetylated LDL and has little activity in internalising modified LDL. It can interact with SCARF1 through its extracellular domain.
SCARF2 is also known as SREC-II, SREC2 and HUMZD58C02. Its former name was scavenger receptor class F, member 2. RefSeq reports alternatively spliced transcript variants that encode distinct isoforms, so check which isoform your work needs to detect.
A mouse ortholog, Scarf2, is recorded for the human gene. The data supplied give no rat ortholog. Researchers using SCARF2 antibody or SCARF2 ELISA kit reagents in other species should check the datasheet of any product for its validated reactivity.
Other class F scavenger receptors and lipoprotein-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96GP6; product specifications from Assay Genie datasheets.