RAMP3
RAMP3 (receptor activity modifying protein 3) is a single-pass membrane accessory protein that interacts with G protein-coupled receptors and modulates their function. It belongs to the RAMP family and helps determine which ligands a partner receptor recognises. Browse Assay Genie's current range of RAMP3 research reagents below, or read on for the biology behind the target.
RAMP3 is an accessory protein that interacts with and modulates the function of G protein-coupled receptors, including the calcitonin gene-related peptide type 1 receptor (CALCRL), the calcitonin receptor (CALCR) and G protein-coupled oestrogen receptor 1 (GPER1). It is required for the transport of CALCRL and GPER1 to the plasma membrane. Together with CALCRL, RAMP3 forms a receptor complex for adrenomedullin (ADM) and intermedin (ADM2). Together with CALCR, it forms a receptor complex for amylin (IAPP).
The RAMP3 protein is a member of the RAMP family of single-transmembrane-domain proteins. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. CALCRL (also called CRLR) has seven transmembrane domains and can act as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which RAMP family members are expressed. When RAMP3 is present, CRLR functions as an adrenomedullin receptor. The protein is found at the cell membrane.
RAMP3 has also been linked to cardioprotection: it reduces cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. HGNC places the RAMP3 gene in the group of receptor (G protein-coupled) activity modifying proteins, and orthologous genes are annotated in mouse and rat (Ramp3). This makes RAMP3 a useful subject for studying how accessory proteins shape GPCR trafficking and ligand selectivity.
RAMP3 is required to transport CALCRL and GPER1 to the plasma membrane, making it a model for accessory-protein control of receptor localisation.
With CALCRL, RAMP3 forms a receptor complex for adrenomedullin and intermedin, so it is central to work on how these peptides signal.
Together with CALCR, RAMP3 acts as a receptor complex for amylin, supporting research on how RAMP partners define calcitonin-family receptor pharmacology.
RAMP3 reduces cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner, linking it to cardioprotection.
RAMP3 is an accessory protein that interacts with G protein-coupled receptors and modulates their function. It is needed to carry CALCRL and GPER1 to the plasma membrane, and it shapes ligand preference: with CALCRL it forms an adrenomedullin receptor, and with CALCR it forms an amylin receptor complex.
The HGNC name is receptor activity modifying protein 3, and UniProt lists it as receptor activity-modifying protein 3. No other aliases are recorded. It belongs to the RAMP family, also called receptor (calcitonin) activity modifying proteins, which are single-pass type I transmembrane proteins.
Orthologous genes named Ramp3 are annotated in both mouse and rat. In terms of physiology, RAMP3 plays a role in cardioprotection, reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Check the datasheet of any product for its validated reactivity.
Other RAMP family members and related GPCR accessory proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60896; product specifications from Assay Genie datasheets.