SPATA16 is required for spermiogenesis, the late phase of spermatogenesis in which round spermatids differentiate into mature sperm, and it is essential for male fertility. UniProt annotates it as involved in formation of the sperm acrosome, the secretory vesicle-derived structure that caps the sperm head. Consistent with this role, the protein is found in the Golgi apparatus and in the acrosome of cytoplasmic secretory vesicles.

The SPATA16 gene encodes a testis-specific protein that belongs to the SPATA16 family and to the tetratricopeptide repeat-like superfamily. According to the NCBI Gene summary, the encoded protein localises to the Golgi apparatus and may play a role in spermatogenesis. Its restriction to the testis makes SPATA16 a useful marker when studying male germ cell biology. A mouse ortholog, Spata16, is recognised, which allows the protein to be studied in a model organism.

The alias NYD-SP12 is still used in the literature alongside the approved HGNC name, spermatogenesis associated 16. Researchers working on acrosome biogenesis, Golgi-derived vesicle trafficking in germ cells and the molecular basis of male infertility may encounter either name when searching for SPATA16 antibody, SPATA16 ELISA kit or SPATA16 protein reagents.