TFG
TFG (trafficking from ER to Golgi regulator, previously TRK-fused gene) is an endoplasmic reticulum protein required for secretory cargo traffic to the Golgi apparatus. It is also known as TF6, FLJ36137 and SPG57, and is implicated in several oncogenic gene rearrangements. Browse Assay Genie's current range of TFG research reagents below, or read on for the biology behind the target.
TFG plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. It is required for secretory cargo traffic from the ER to the Golgi apparatus, the first step in the secretory pathway. UniProt records its subcellular location as the endoplasmic reticulum.
The human TFG gene encodes the protein TFG, catalogued by UniProt as Protein TFG. Multiple transcript variants have been found for this gene. The official HGNC name, trafficking from ER to golgi regulator, describes its role in cargo transport, while the earlier name, TRK-fused gene, reflects its history as a fusion partner. Other designations include TF6, FLJ36137 and SPG57.
TFG is of interest in cancer biology. The NCBI Gene summary notes several documented fusion oncoproteins encoded partially by this gene, and the gene participates in oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma. It may also play a role in the NF-kappaB pathway. Researchers studying the TFG protein therefore work across secretory trafficking and tumour biology.
TFG is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus, making it a focus for studies of early secretion.
TFG contributes to the normal dynamic function of the endoplasmic reticulum and its associated microtubules.
TFG is partially encoded in several fusion oncoproteins and participates in rearrangements linked to anaplastic lymphoma and mixoid chondrosarcoma.
TFG may play a role in the NF-kappaB pathway, offering a route to investigate its signalling functions.
TFG plays a role in the normal dynamic function of the endoplasmic reticulum and its associated microtubules. It is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. The NCBI Gene summary also suggests it may play a role in the NF-kappaB pathway.
The HGNC name is trafficking from ER to golgi regulator, and the previous name was TRK-fused gene. Aliases and previous symbols include TF6, FLJ36137 and SPG57. UniProt lists the protein as Protein TFG. Multiple transcript variants have been reported for the gene.
NCBI Gene reports several fusion oncoproteins encoded partially by TFG. The gene participates in oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma. Check the datasheet of any product for its validated reactivity before planning cross-species work.
Other secretory pathway, ER trafficking and NF-kappaB signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92734; product specifications from Assay Genie datasheets.