CDK14
CDK14 (cyclin dependent kinase 14, also known as PFTAIRE1 or PFTK1) is a serine/threonine-protein kinase that helps control the eukaryotic cell cycle, with its activity governed by an associated cyclin. It links cell cycle progression to Wnt signalling during the G2/M phase. Browse Assay Genie's current range of CDK14 research reagents below, or read on for the biology behind the target.
CDK14 is a serine/threonine-protein kinase involved in control of the eukaryotic cell cycle, and its activity depends on an associated cyclin. During the G2/M phase it acts as a cell-cycle regulator of the Wnt signalling pathway by phosphorylating LRP6 at Ser-1490, which leads to activation of Wnt signalling. It also regulates cell cycle progression and cell proliferation through its interaction with CCDN3. In vitro, CDK14 phosphorylates RB1, although the relevance of this result in vivo remains to be confirmed.
The protein belongs to the protein kinase superfamily, in the CMGC Ser/Thr protein kinase family and the CDC2/CDKX subfamily. HGNC places the CDK14 gene in the cyclin dependent kinases group. NCBI Gene annotates the protein with cyclin binding and cyclin-dependent protein serine/threonine kinase activity, and describes it as part of the cytoplasmic cyclin-dependent protein kinase holoenzyme complex. It is located in the cytosol, nucleoplasm and plasma membrane, and UniProt lists cell membrane, cytoplasm and nucleus. The mouse ortholog is Cdk14.
Beyond the G2/M transition of the mitotic cell cycle and regulation of canonical Wnt signalling, UniProt notes that CDK14 may also play a role in meiosis and neuron differentiation. It may indirectly act as a negative regulator of insulin-responsive glucose transport. The name PFTAIRE protein kinase 1 (PFTK1, PFTAIRE1) is the previous HGNC name and symbol for the gene, and it is now designated cyclin dependent kinase 14.
CDK14 is a cyclin-dependent kinase that controls cell cycle progression and proliferation, including through its interaction with CCDN3.
CDK14 phosphorylates LRP6 at Ser-1490 during G2/M, activating the Wnt signalling pathway in a cell cycle-dependent manner.
CDK14 is involved in the G2/M transition of the mitotic cell cycle, making it relevant to mitotic control research.
CDK14 may play a role in meiosis and neuron differentiation, and may indirectly regulate insulin-responsive glucose transport.
CDK14 is a cyclin-dependent serine/threonine kinase that regulates cell cycle progression and proliferation. During G2/M it phosphorylates LRP6 at Ser-1490, activating Wnt signalling. It also interacts with CCDN3, and may contribute to meiosis, neuron differentiation and indirect control of insulin-responsive glucose transport.
CDK14 is also called PFTAIRE1 and PFTK1, and its previous HGNC name was PFTAIRE protein kinase 1. The current approved name is cyclin dependent kinase 14. UniProt uses the protein name cyclin-dependent kinase 14, and the enzyme carries EC number 2.7.11.22.
A mouse ortholog, Cdk14, is recorded for the human gene. CDK14 belongs to the CMGC Ser/Thr protein kinase family and the CDC2/CDKX subfamily. Check the datasheet of any product for its validated reactivity.
Other cyclin-dependent kinases and CDK inhibitors involved in cell cycle control, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O94921; product specifications from Assay Genie datasheets.