TRIP10
TRIP10 (thyroid hormone receptor interactor 10), also known as CIP4, STP, HSTP and STOT, is a Cdc42-interacting F-BAR protein that links membrane remodelling to the actin cytoskeleton. It acts in endocytosis, insulin-stimulated GLUT4 translocation and podosome formation. Browse Assay Genie's current range of TRIP10 research reagents below, or read on for the biology behind the target.
TRIP10 coordinates membrane tubulation with reorganisation of the actin cytoskeleton during endocytosis. The protein binds lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine, and promotes membrane invagination and the formation of tubules. It also promotes CDC42-induced actin polymerisation by recruiting WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerisation may then drive the fission of membrane tubules to form endocytic vesicles.
Beyond endocytosis, TRIP10 is required for translocation of GLUT4 to the plasma membrane in response to insulin signalling, and for the formation of podosomes, the actin-rich adhesion structures specific to monocyte-derived cells. It may also be required for the lysosomal retention of FASLG/FASL. UniProt records the protein in the cytoplasm, including the cytoskeleton, cell cortex and perinuclear region, as well as the lysosome, Golgi apparatus, cell membrane and phagocytic cup. NCBI Gene lists it as located in extracellular exosome and enabling identical protein binding.
The human TRIP10 gene encodes Cdc42-interacting protein 4, a member of the FNBP1 family. HGNC places it in the F-BAR domain containing and SH3 domain containing gene groups, and also in the minor histocompatibility antigens group. Previous symbols include STP, HSTP, CIP4 and STOT, and the previous name was salt tolerator. NCBI Gene describes it as a biomarker of Huntington's disease. Mouse and rat both carry a Trip10 ortholog.
TRIP10 is required for GLUT4 translocation to the plasma membrane in response to insulin signalling, making it relevant to glucose uptake studies.
Through lipid binding and membrane tubulation, TRIP10 couples tubule formation to actin dynamics during endocytosis.
TRIP10 recruits WASL/N-WASP to promote CDC42-induced actin polymerisation and is required for podosome formation in monocyte-derived cells.
NCBI Gene describes TRIP10 as a biomarker of Huntington's disease, supporting its study in neurodegeneration research.
TRIP10 binds phosphoinositide and phosphatidylserine lipids, promotes membrane invagination and tubule formation, and recruits WASL/N-WASP to drive CDC42-induced actin polymerisation. It is needed for insulin-stimulated GLUT4 translocation and for podosome formation. Check the datasheet of any product for its validated reactivity.
TRIP10 is also called CIP4, from its UniProt name Cdc42-interacting protein 4, and STP, HSTP and STOT. The previous HGNC name was salt tolerator. The HGNC full name is thyroid hormone receptor interactor 10.
Yes. Both mouse and rat have a Trip10 ortholog of the human gene. The protein belongs to the FNBP1 family and carries F-BAR and SH3 domains. TRIP10 is also noted as a biomarker of Huntington's disease in NCBI Gene.
Other thyroid hormone receptor interactor family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15642; product specifications from Assay Genie datasheets.