SIGLEC1
SIGLEC1 (sialic acid binding Ig like lectin 1), also known as sialoadhesin, SIGLEC-1 or CD169, is a lectin-like adhesion molecule of the immunoglobulin superfamily. It binds sialylated glycoconjugates on cell surfaces and mediates cell-cell interactions. Browse Assay Genie's current range of SIGLEC1 research reagents below, or read on for the biology behind the target.
SIGLEC1 is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is described as a type I transmembrane protein and is involved in mediating cell-cell interactions. UniProt records both cell membrane and secreted locations for the protein.
The SIGLEC1 gene encodes a member of the immunoglobulin superfamily and of the SIGLEC (sialic acid binding Ig-like lectin) family. According to NCBI Gene, the protein is expressed only by a subpopulation of macrophages, which makes it a useful reference point when studying macrophage heterogeneity. HGNC places it in the groups of CD molecules and sialic acid binding Ig like lectins, and its extracellular region contains V-set, C2-set and I-set immunoglobulin-like domains. The mouse ortholog is Siglec1.
The protein was first named sialoadhesin, and the name remains in use alongside CD169 and SIGLEC-1. Its role in infection is a major reason for research interest. UniProt notes that it facilitates viral cytoplasmic entry into activated dendritic cells by recognising sialylated gangliosides present on the viral membrane. NCBI Gene adds that the protein plays an important role in multiple human diseases and in bacterial and viral infections, and that it has been shown to enhance SARS-CoV-2 infection. Studies of the SIGLEC1 gene and SIGLEC1 protein therefore span glycobiology, innate immunity and virology.
SIGLEC1 is expressed only by a subpopulation of macrophages, so it is relevant to studies of macrophage subsets and their cell-cell interactions.
SIGLEC1 recognises sialylated gangliosides on viral membranes and facilitates viral cytoplasmic entry into activated dendritic cells.
SIGLEC1 has been shown to enhance SARS-CoV-2 infection, making it a focus for work on host factors in viral infection.
As a sialic acid-binding lectin of the SIGLEC family, it is used to explore sialic acid-dependent recognition of glycoconjugates on cell surfaces.
SIGLEC1 is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner and mediates cell-cell interactions. It also facilitates viral entry into activated dendritic cells by recognising sialylated gangliosides on viral membranes.
SIGLEC1 is also called sialoadhesin, SIGLEC-1, CD169 and SN. Older names include sialic acid binding Ig-like lectin 1. Clone-derived aliases such as FLJ00051, FLJ00055, FLJ00073, FLJ32150 and dJ1009E24.1 also appear in some records.
NCBI Gene reports that SIGLEC1 plays an important role in multiple human diseases and in bacterial and viral infections, including enhancement of SARS-CoV-2 infection. The mouse ortholog is Siglec1; check the datasheet of any product for its validated reactivity.
Other members of the SIGLEC family of sialic acid binding Ig-like lectins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BZZ2; product specifications from Assay Genie datasheets.