TTC23
TTC23 (tetratricopeptide repeat domain 23) is a cilium-associated protein that participates positively in ciliary Hedgehog signalling. It is also known as FLJ12572 and HCC-8, and belongs to the tetratricopeptide repeat domain containing gene group. Browse Assay Genie's current range of TTC23 research reagents below, or read on for the biology behind the target.
TTC23 participates positively in the ciliary Hedgehog (Hh) signalling pathway. The NCBI Gene summary, provided by the Alliance of Genome Resources, describes it as predicted to be involved in positive regulation of the smoothened signalling pathway, and predicted to be located in the cilium. UniProt lists its subcellular location as a cell projection, specifically the cilium, which fits a role in signalling that is organised at this structure.
The human TTC23 gene encodes tetratricopeptide repeat protein 23. The gene is classified by HGNC in the tetratricopeptide repeat domain containing group, a large set of genes whose products carry tetratricopeptide repeat motifs. Orthologues are annotated in mouse and rat, both named Ttc23, so rodent systems can be used to study the gene.
The alternative designations FLJ12572 and HCC-8 appear in older literature and database records, so searching under all three names helps when reviewing earlier work. Current annotation is limited, and much of the functional picture for TTC23 rests on a short UniProt statement and computational prediction. This makes the protein of interest for researchers working on cilia biology and Hedgehog pathway regulation, where its precise molecular role remains to be defined.
TTC23 participates positively in ciliary Hedgehog signalling and is predicted to regulate the smoothened signalling pathway.
UniProt places TTC23 in the cilium, making it a candidate for studies of ciliary protein organisation and function.
TTC23 belongs to the tetratricopeptide repeat domain containing gene group, useful for comparing members of this large protein class.
Mouse and rat both carry a Ttc23 orthologue, supporting cross-species investigation of its ciliary role.
UniProt reports that TTC23 participates positively in ciliary Hedgehog (Hh) signalling. The NCBI Gene summary adds that it is predicted to be involved in positive regulation of the smoothened signalling pathway and to be located in the cilium. Detailed molecular mechanisms are not yet described in these sources.
TTC23 stands for tetratricopeptide repeat domain 23, and UniProt names the product tetratricopeptide repeat protein 23. Aliases include FLJ12572 and HCC-8. Searching under each name can help when reading older papers or database entries that predate the current symbol.
Yes, orthologues named Ttc23 are annotated in both mouse and rat. This allows rodent models to be considered for studying the gene's role in ciliary Hedgehog signalling. Check the datasheet of any product for its validated reactivity.
Hedgehog pathway components and other ciliary or tetratricopeptide repeat proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5W5X9; product specifications from Assay Genie datasheets.