HCN1
HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1, also known as BCNG-1, BCNG1 and HAC-2) is a hyperpolarization-activated cation channel permeable to sodium and potassium ions. It contributes to native pacemaker currents in heart and neurons. Browse Assay Genie's current range of HCN1 research reagents below, or read on for the biology behind the target.
HCN1 is a hyperpolarization-activated ion channel that is permeable to both sodium and potassium ions, with lower selectivity for K(+) over Na(+). Because the channel opens in response to hyperpolarization, it supplies an inward current that helps set the rhythm and excitability of the cells that express it. It contributes to the native pacemaker current in the heart (If) and to the I(h) current, which controls neuronal excitability.
The HCN1 protein is a membrane protein found at the cell membrane. According to the NCBI Gene summary, it can homodimerize or heterodimerize with other pore-forming subunits to form a channel, so the properties of native currents may depend on which HCN subunits are combined. HCN2 and HCN4 are other members of the same potassium channel HCN family. The HCN1 gene belongs to the HGNC gene group of cyclic nucleotide gated channels, and mouse and rat each carry an orthologous Hcn1 gene.
Functional annotation links HCN1 to cerebellar mechanisms of motor learning, and it may mediate responses to sour stimuli; the encoded channel may act as a receptor for sour tastes. The names BCNG-1 and HAC-2 reflect earlier nomenclature for the gene, and its HGNC name has also been written with a hyphen as hyperpolarization activated cyclic nucleotide-gated potassium channel 1. Researchers studying cardiac pacemaking, neuronal excitability, motor learning or taste signalling work with HCN1 as one of the channel subunits underlying these processes.
HCN1 contributes to the native pacemaker current (If) in the heart, making it relevant to studies of cardiac rhythm generation.
HCN1 contributes to the I(h) current, which controls neuron excitability, so it is a subject of neurophysiology research.
HCN1 participates in cerebellar mechanisms of motor learning, linking channel function to behaviour and circuit studies.
HCN1 may mediate responses to sour stimuli and may act as a sour taste receptor, a topic in sensory biology.
HCN1 forms a hyperpolarization-activated channel permeable to sodium and potassium ions, with lower selectivity for K(+) over Na(+). It contributes to cardiac pacemaker currents (If) and the neuronal I(h) current that controls excitability. It also participates in cerebellar motor learning and may mediate responses to sour stimuli.
HCN1 is also known as BCNG-1, BCNG1 and HAC-2. UniProt names it potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. HGNC previously used a hyphenated form, hyperpolarization activated cyclic nucleotide-gated potassium channel 1, for the full gene name.
Yes. Both mouse and rat have an orthologous gene named Hcn1, so the channel can be studied in rodent models. HCN1 also belongs to the potassium channel HCN family alongside HCN2 and HCN4; check the datasheet of any product for its validated reactivity.
Other HCN family channels that can form heteromeric pacemaker channels with HCN1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60741; product specifications from Assay Genie datasheets.