DVL1
DVL1 is the human homologue of the Drosophila dishevelled gene (dsh) and encodes a cytoplasmic phosphoprotein that transduces Wnt signals. It binds frizzled family members and passes the signal to downstream effectors in both canonical and non-canonical Wnt signalling. Browse Assay Genie's current range of DVL1 research reagents below, or read on for the biology behind the target.
DVL1 participates in Wnt signalling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to downstream effectors. It acts in both canonical and non-canonical Wnt signalling, and in signal transduction pathways mediated by multiple Wnt genes. DVL1 is required for LEF1 activation upon WNT1 and WNT3A signalling.
DVL1 also has a role at the neuromuscular junction. DVL1 and PAK1 form a ternary complex with MUSK, which is important for MUSK-dependent regulation of AChR clustering during formation of the neuromuscular junction. The protein is found at the cell membrane, in the cytosol and in cytoplasmic vesicles. It belongs to the DSH family, and HGNC places the gene among the dishevelled segment polarity proteins, PDZ domain containing and DEP domain containing groups. The same gene group listing also classes it as a microRNA protein coding host gene. Mouse and rat both carry a Dvl1 ortholog.
The human gene was named as the homologue of Drosophila dishevelled (dsh), and earlier HGNC names include dishevelled 1 (homologous to Drosophila dsh). According to the NCBI Gene summary, DVL1 regulates cell proliferation as a transducer molecule for developmental processes, including segmentation and neuroblast specification. It is a candidate gene for neuroblastomatous transformation. Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same chromosomal region, and their phenotypes may be consistent with aberrant expression of a DVL gene during development.
DVL1 transduces signals from frizzled receptors to downstream effectors, making it a central node in canonical and non-canonical Wnt pathways.
As a homologue of Drosophila dishevelled, DVL1 acts as a transducer in developmental processes including segmentation and neuroblast specification.
A DVL1, PAK1 and MUSK ternary complex regulates AChR clustering during neuromuscular junction formation.
DVL1 regulates cell proliferation and is a candidate gene for neuroblastomatous transformation, linking it to cancer and neurological disease research.
DVL1 participates in Wnt signalling by binding the cytoplasmic C-terminus of frizzled family members and transducing the signal to downstream effectors. It functions in canonical and non-canonical pathways and is required for LEF1 activation upon WNT1 and WNT3A signalling.
The HGNC full name is dishevelled segment polarity protein 1, and UniProt lists segment polarity protein dishevelled homolog DVL-1. Earlier names were dishevelled 1 (homologous to Drosophila dsh) and dishevelled, dsh homolog 1 (Drosophila). No alternative gene symbols are recorded.
DVL1 is the human homologue of Drosophila dishevelled, and mouse and rat both have a Dvl1 ortholog. It is a candidate gene for neuroblastomatous transformation, and Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A map to the same region. Check the datasheet of any product for its validated reactivity.
Other dishevelled family members and Wnt pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14640; product specifications from Assay Genie datasheets.