NTSR2
NTSR2 (neurotensin receptor 2, also known as NTR2) is a G protein-coupled receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Browse Assay Genie's current range of NTSR2 research reagents below, or read on for the biology behind the target.
NTSR2 is a receptor for neurotensin, a tridecapeptide. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system, so ligand binding at the cell surface is coupled to intracellular calcium signalling. The protein is localised to the cell membrane.
The NTSR2 gene encodes a member of the G protein-coupled receptor 1 family, within the neurotensin receptor subfamily, where NTSR2 forms its own sub-subfamily. HGNC places it in the neurotensin receptors gene group, alongside NTSR1. Mouse and rat both carry an Ntsr2 ortholog.
Binding and pharmacological studies show that this receptor binds neurotensin and several other ligands already described for the neurotensin NT1 receptor (NTSR1). Unlike NT1, however, NTSR2 recognises levocabastine, a histamine H1 receptor antagonist, with high affinity. Levocabastine had previously been shown to compete with neurotensin for low-affinity binding sites in brain. These properties suggest that the receptor may be of physiological importance and that a natural agonist for it may exist. Researchers studying neurotensin signalling often examine the NTSR2 protein alongside NTSR1 to separate the contributions of each receptor.
NTSR2 is a receptor for neurotensin and couples to a phosphatidylinositol-calcium second messenger system, making it relevant to studies of neurotensin-driven pathways.
Binding studies show NTSR2 recognises levocabastine with high affinity, a property that distinguishes it from the NT1 receptor in ligand-selectivity work.
Levocabastine competes with neurotensin at low-affinity binding sites in brain, linking NTSR2 to investigations of neurotensin binding in neural tissue.
Its pharmacology suggests a natural agonist may exist, which keeps NTSR2 a subject of interest in the search for additional endogenous ligands.
NTSR2 is a cell-membrane receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. It also binds several other ligands described for the NT1 receptor, and recognises levocabastine with high affinity.
The HGNC-approved name is neurotensin receptor 2, and UniProt lists it as neurotensin receptor type 2. The alias NTR2 is also used. The related NT1 receptor is encoded by NTSR1. Both belong to the HGNC neurotensin receptors gene group.
Yes. Mouse and rat both have an Ntsr2 ortholog of the human NTSR2 gene. Reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
The related neurotensin receptor NTSR1 and other targets in neurotensin signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95665; product specifications from Assay Genie datasheets.